25617-45-2

Basic information

• Product Name: N-(4-(trifluoromethyl)phenyl)nicotinamide
• Synonyms: N-(4-(trifluoromethyl)phenyl)nicotinamide
• CAS NO: 25617-45-2
• Molecular Weight: 266.222
• Mol File: 25617-45-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-(trifluoromethyl)phenyl)nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(trifluoromethyl)phenyl)nicotinamide(25617-45-2)
• EPA Substance Registry System: N-(4-(trifluoromethyl)phenyl)nicotinamide(25617-45-2)

Safety Data

• Hazardous Substances Data: 25617-45-2(Hazardous Substances Data)

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 455-14-1 4-trifluoromethylphenylamine 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 98-92-0 nicotinamide 
• 98-56-6 4-chlorobenzotrifluoride 

Relevant articles and documents

Preparation method of compound containing bipyrazole ring and intermediate thereof

The invention discloses a preparation method of a compound containing a bipyrazole ring and an intermediate of the compound. The preparation method of a bipyrazole ring-containing compound as shown ina formula I comprises the following steps: (1) adding alkali into a mixture of a bipyrazole ring compound as shown in a formula I-1 and a solvent for replacement reaction to obtain a mixed system; and (2) adding an organic phosphorus compound shown as a formula I-2 into the mixed system in the step (1), and carrying out a phosphonation reaction shown in the specification, so as to obtain the bipyrazole ring-containing compound shown as the formula I, wherein R1 and R2 are independently a C1-C6 alkyl group, a C3-C8 cycloalkyl group and a phenyl group, R3 is a C1-C6 alkyl group, and X is halogen. The prepared compound containing a bipyrazole ring can be used as a ligand, and is suitable for the application range of amide in C-N coupling and the C-C coupling reaction of arylboronic acid andaryl chloride.

Efficient conversion of acids and esters to amides and transamidation of primary amides using OSU-6

OSU-6, an MCM-41 type hexagonal mesoporous silica with strong Bronsted acid properties, has been used to promote the high-yield conversion of carboxylic acids and esters to carboxamides as well as transamidations of primary amides in a one-pot solventless approach. A metal-free heterogeneous catalyst that promotes all of these processes has not been previously reported. OSU-6 enables these transformations to proceed in shorter times and at lower temperatures for a broad range of substrates. An added benefit is that the catalyst can be recycled and reused multiple times without significant loss of activity.