2562-38-1 Usage
Description
Nitrocyclopentane, a secondary nitroalkane, is a clear pale yellow liquid that has been examined for its ability to induce DNA repair in rat hepatocytes. The nitronate of nitrocyclopentane was found to be mutagenic in Salmonella strains TA100 and TA102.
Uses
Used in Pharmaceutical Industry:
Nitrocyclopentane is used as a research compound for its potential role in DNA repair mechanisms and mutagenic properties. Its ability to induce DNA repair in rat hepatocytes makes it a valuable tool for studying the processes involved in cellular repair and mutagenesis.
Used in Chemical Research:
As a secondary nitroalkane, nitrocyclopentane is used in chemical research to understand the properties and reactions of nitroalkanes. This knowledge can be applied to the development of new chemical compounds and materials with various applications.
Used in Environmental Studies:
The mutagenic properties of nitrocyclopentane's nitronate in Salmonella strains can be utilized in environmental studies to assess the potential mutagenic effects of pollutants or other substances on bacterial strains. This can help in understanding the impact of environmental factors on genetic mutations and the development of new strategies for environmental protection and remediation.
Preparation
Bromocyclopentane (22.0 g, 0.15 mol) was added to a soln of NaNO2 (18 g, 0.26 mol) in dry DMSO (100 mL) at 15 ℃ and the mixture was stirred at this temperature for 3 h. The mixture was poured into ice water (250 mL) and extracted with petroleum ether (bp 35-37 ℃; 4 × 50 mL). The combined organic extracts were washed with H2O (4× 50 mL), dried (MgSO4), and concentrated under reduced pressure. The residue was distilled to give Nitrocyclopentane; yield: 9.9 g (58%); bp 62 ℃/8 Torr; nD/20 1.4538.
Synthesis of Nitrocyclopentane
Synthesis Reference(s)
Tetrahedron Letters, 21, p. 1117, 1980 DOI: 10.1016/S0040-4039(01)83928-9
Check Digit Verification of cas no
The CAS Registry Mumber 2562-38-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,6 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2562-38:
(6*2)+(5*5)+(4*6)+(3*2)+(2*3)+(1*8)=81
81 % 10 = 1
So 2562-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO2/c7-6(8)5-3-1-2-4-5/h5H,1-4H2
2562-38-1Relevant articles and documents
-
Kornblum,Powers
, p. 455 (1957)
-
Facile access to nitroalkanes: Nitration of alkanes by selective C[sbnd]H nitration using metal nitrate, catalyzed by in-situ generated metal oxide
Li, Na,Mao, Liqiu,Peng, Haoyu,Peng, Ling,Yin, Dulin,You, Kuiyi,Zhong, Wenzhou
, (2020/05/13)
Direct C ? H functionalization of inactive alkanes is an important strategy to streamline the preparation of functional molecules. Herein, we describe an operationally simple and effective alkane C ? H nitration reaction to access versatile nitroalkanes without cleavage of the C ? C skeleton. Nontoxic and inexpensive metal nitrate (Fe(NO3)3·9H2O) plays a dual role as catalyst precursors as well as nitro sources for the transformation. Experimental evidence and theoretical modeling have shown the formation of iron oxide as a key catalytic species for the alkane C ? H and NO2 activation, which favors a stepwise radical mechanism with initial alkyl radical formation.
Green synthesis method for preparing nitroalkanes by oxime oxidation
-
Paragraph 0037; 0038, (2017/08/29)
The invention belongs to the field of organic chemical industries, and provides a green synthesis method for preparing nitroalkanes by oxime oxidation. At the temperature of 55 to 120 DEG C and under the pressure of 0 to 1.0 MPa, oxime, a solvent and hydrogen peroxide are reacted for 20 to 200min in the presence of certain amounts of nanoporous skeleton metal hybrid catalysts and cocatalysts, a reaction liquid is subjected to membrane separation, the catalysts can be repeatedly used for more than 7 times, and distilled to obtain nitroalkane products, the purity of the products is not less than 99%, and the yield of the products is not less than 95%. Furthermore, the green synthesis method for preparing nitroalkanes by the oxime oxidation disclosed by the invention is a green synthesis method of nitroalkanes, and suitable for large-scale industrialized production.
