256327-65-8

Basic information

• Product Name: 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester
• Synonyms: 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester
• CAS NO: 256327-65-8
• Molecular Weight: 1104.25
• Mol File: 256327-65-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester(256327-65-8)
• EPA Substance Registry System: 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester(256327-65-8)

Safety Data

• Hazardous Substances Data: 256327-65-8(Hazardous Substances Data)

Upstream product

• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 256327-64-7 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3S,4R,6S)-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-4-hydroxy-2-methyl-tetrahydro-pyran-3-yl ester 
• 256327-77-2 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-4-allyloxy-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-3-yl ester 
• 256327-61-4 C₅₃H₇₆O₁₀SSi₂ 
• 256327-62-5 (2R,3R,4S,5R)-4-Benzyloxy-3-[(2S,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yloxy]-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran 
• 256327-63-6 (2R,3R,4R,6S)-4-Allyloxy-6-[(2R,3R,4S,5R)-4-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-3-ol 
• 256327-76-1 (2R,3S,4R,6S)-6-[(2R,3R,4S,5R)-4-Benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-3,4-diol 
• 256327-59-0 [(2R,3R,4R,5R)-4-Benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-yloxy]-tert-butyl-dimethyl-silane 
• 256327-73-8 Toluene-4-sulfonic acid (3aS,4R,6R,7R,7aR)-2,2-dimethyl-4-phenylsulfanyl-7-triisopropylsilanyloxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ylmethyl ester 
• 256327-56-7 (2R,3R,4R,5S,6R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-6-phenylsulfanyl-tetrahydro-pyran 
• 256327-46-5 (2R,3R,4S,5R)-4-Benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-2-methyl-tetrahydro-pyran-3-ol 
• 256327-54-5 (2R,3S,4R,5S,6R)-3-(4-Methoxy-benzyloxy)-6-methyl-2-phenylsulfanyl-5-triisopropylsilanyloxy-tetrahydro-pyran-4-ol 
• 256327-57-8 (2R,3S,4R,5R,6R)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-ol 
• 306768-24-1 (2R,3R,4S,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-6-fluoro-2-methyl-5-phenylsulfanyl-tetrahydro-pyran 

Downstream Products

• 256327-69-2 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3S,4R,6S)-6-((2R,3R,4S,5R,6S)-5-acetoxy-4-benzyloxy-2-methyl-6-phenylselanyl-tetrahydro-pyran-3-yloxy)-4-hydroxy-2-methyl-tetrahydro-pyran-3-yl ester 
• 256327-66-9 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-((2R,3R,4S,5R)-5,6-diacetoxy-4-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester 
• 256327-79-4 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-((2R,3R,4S,5R,6S)-5-acetoxy-4-benzyloxy-2-methyl-6-phenylselanyl-tetrahydro-pyran-3-yloxy)-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester 
• 256327-68-1 4-Benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid (2R,3R,4R,6S)-6-[(2R,3R,4S,5R)-5-acetoxy-4-benzyloxy-2-methyl-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-2-methyl-4-triisopropylsilanyloxy-tetrahydro-pyran-3-yl ester 
• 256327-71-6 4-benzyloxy-3,5-dichloro-2-methoxy-6-methyl-benzoic acid 6-(4-benzyloxy-5-hydroxy-2-methyl-6-phenylselanyl-tetrahydro-pyran-3-yloxy)-4-(5-methoxy-4,6-dimethyl-4-nitro-tetrahydro-pyran-2-yloxy)-2-methyl-tetrahydro-pyran-3-yl ester 

Relevant articles and documents

Total synthesis of everninomicin 13,384-1 - Part 1: Synthesis of the A1B(A)C fragment

The powerful antibiotic everninomicin 13,384-1 (1, Ziracin) has been prepared for the first time through a total synthesis. The (1 → 1-disaccharide and the two orthoesters of this target molecule were introduced by new methodologies using a tin acetal and 1,2-phenylseleno migrations. The reaction sequence also relies on stereoselective glycosidations and subtle manipulations of protecting groups. In addition to the introduction of new synthetic methodologies, this total synthesis should allow the preparation of combinatorial libraries of semisynthetic analogues of this highly promising antibiotic for biological screening purposes.