256334-95-9

Basic information

• Product Name: tert-butyl-dimethyl-(3-nitro-benzyloxy)-silane
• Synonyms: tert-butyl-dimethyl-(3-nitro-benzyloxy)-silane
• CAS NO: 256334-95-9
• Molecular Weight: 267.4
• Mol File: 256334-95-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl-dimethyl-(3-nitro-benzyloxy)-silane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-dimethyl-(3-nitro-benzyloxy)-silane(256334-95-9)
• EPA Substance Registry System: tert-butyl-dimethyl-(3-nitro-benzyloxy)-silane(256334-95-9)

Safety Data

• Hazardous Substances Data: 256334-95-9(Hazardous Substances Data)

Upstream product

• 619-25-0 3-Nitrobenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 913532-36-2 4-(3-hydroxymethyl-phenylamino)-3-nitro-benzoic acid ethyl ester 
• 913532-35-1 3-amino-4-(3-hydroxymethyl-phenylamino)-benzoic acid ethyl ester 
• 913532-34-0 1-(3-hydroxymethyl-phenyl)-1H-benzoimidazole-5-carboxylic acid ethyl ester 
• 159217-95-5 3-[[tert-butyl(dimethyl)silyl]-oxymethyl]aniline 
• 619-25-0 3-Nitrobenzyl alcohol 

Relevant articles and documents

A mild and highly efficient method for the preparation of silyl ethers using Fe(HSO4)3/Et3N by chlorosilanes

Avery efficient and mild procedure for preparation of silyl ethers from benzylic, allylic, propargilic alcohols, phenols, naphtoles and some of phenolic drugs with trimethylsilylchloride (TMSCl), triethylsilylchloride (TESCl) and t-buthyldimethylsilyl chloride (TDSCl) ethers in the presence of Fe(HSO 4)3/Et3N in roomtemperature in excellent yields is reported. This procedure also allows the excellent selectivity for silylation of alcohols and phenols.

BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX

This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.