2565-01-7

Basic information

• Product Name: (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline
• Synonyms: (S)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6-methyl-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinolin; 4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (6aS)-; 4H-Benzo[de][1,3]benzodioxolo[5,6-g]quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (S)-; 6a.alpha.-Aporphine, 1,2-dimethoxy-9,10-(methylenedioxy)-
• CAS NO: 2565-01-7
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.385
• Mol File: 2565-01-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 487.5°C at 760 mmHg
• Flash Point: 145.2°C
• Density: 1.266g/cm³
• Vapor Pressure: 1.18E-09mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline(2565-01-7)
• EPA Substance Registry System: (6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline(2565-01-7)

Safety Data

• Hazardous Substances Data: 2565-01-7(Hazardous Substances Data)

Usage

General Description

(6aS)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline is a complex organic compound with a long and specific chemical structure. It contains methoxy and methyl groups, as well as a tetrahydrobenzodioxoloquinoline ring system. The presence of these functional groups and ring structures gives the compound potential pharmacological and biological activities. However, due to its complex structure, the compound may have limited practical applications and may require further research to fully understand its properties and potential uses.

Upstream product

• 42971-15-3 (+/-)-nantenine 

Relevant articles and documents

Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine

The naturally occurring aporphine alkaloid nantenine, has been shown to antagonize behavioral and physiological effects of MDMA in mice. We have synthesized (±)-nantenine via an oxidative cyclization reaction with PIFA and evaluated its binding profile against a panel of CNS targets. To begin to understand the importance of the chiral center of nantenine with regards to its capacity to antagonize the effects of MDMA in vivo, (R)- and (S)-nantenine were prepared and evaluated in a food-reinforced operant task in rats. Pretreatment with either nantenine enantiomer (0.3 mg/kg ip) completely blocked the behavioral suppression induced upon administration of 3.0 mg/kg MDMA. (±)-Nantenine displayed high affinity and selectivity for the α1A adrenergic receptor among several other receptors suggesting that this α1 subtype may be significantly involved in the anti-MDMA effects of the enantiomers.