256518-97-5

Basic information

• Product Name: 1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO-
• Synonyms: 1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO-;2-chloro-5-iodo-1H-benzimidazole;2-chloro-5-iodo-1H-benzo[d]iMidazole;2-Chloro-6-iodo-1H-benzimidazole;2-Chloro-5-iodo-1H-benzoimidazole
• CAS NO: 256518-97-5
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 278.48
• Product Categories: Heterocycle-Pyridine series
• Mol File: 256518-97-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409.74 °C at 760 mmHg
• Flash Point: 201.604 °C
• Appearance: /
• Density: 2.156
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.785
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO-(256518-97-5)
• EPA Substance Registry System: 1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO-(256518-97-5)

Safety Data

• Hazardous Substances Data: 256518-97-5(Hazardous Substances Data)

Usage

General Description

1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO- is a chemical composed of a benzimidazole ring with a chlorine atom at the 2nd position and an iodine atom at the 5th position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical has potential applications in the development of new drugs and has been studied for its pharmacological and biological activities. It is important to handle 1H-BENZIMIDAZOLE, 2-CHLORO-5-IODO- with care as it may pose health risks and should be used according to proper safety protocols and regulations.

InChI:InChI=1/C7H4ClIN2/c8-7-10-5-2-1-4(9)3-6(5)11-7/h1-3H,(H,10,11)

Upstream product

• 88-74-4 2-nitro-aniline 
• 20691-72-9 4-iodo-2-nitroaniline 
• 21304-38-1 4-iodobenzene-1,2-diamine 
• 256519-10-5 4-fluoro-1,3-dihydro-2H-1,3-benzimidazole-2-one 
• 40644-14-2 5-iodo-1,3-dihydro-2H-1,3-benzimidazol-2-one 

Downstream Products

• 863222-23-5 2-chloro-5-phenylbenzimidazole 
• 1374771-55-7 2-chloro-6-isopropyl-1H-benzo[d]imidazole 

Relevant articles and documents

Exploring the Strength of the H-Bond in Synthetic Models for Heme Proteins: The Importance of the N?H Acidity of the Distal Base

The distal hydrogen bond (H-bond) in dioxygen-binding proteins is crucial for the discrimination of O2with respect to CO or NO. We report the preparation and characterization of a series of ZnIIporphyrins, with one of three meso-phenyl rings bearing both an alkyl-tethered proximal imidazole ligand and a heterocyclic distal H-bond donor connected by a rigid acetylene spacer. Previously, we had validated the corresponding CoIIcomplexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to CoII-bound dioxygen. Here, we systematically vary the H-bond donor ability of the distal heterocycles, as predicted based on pKavalues. The H-bond in the dioxygen adducts of the CoIIporphyrins was directly measured by Q-band Davies-ENDOR spectroscopy. It was shown that the strength of the hyperfine coupling between the dioxygen radical and the distal H-atom increases with enhanced acidity of the H-bond donor.

FKBP inhibitors

Compounds of formula (I), their salts and solvates, wherein the substituents are as described herein, are FKBP inhibitors.