25684-11-1Relevant articles and documents
Lipoxygenase Inhibitory Activity of Octyl Gallate
Ha, Tae Joung,Nihei, Ken-Ichi,Kubo, Isao
, p. 3177 - 3181 (2004)
Octyl gallate inhibited soybean lipoxygenase-1 (EC 1.13.11-12, type I) with an IC50 of 1.3 μM. The inhibition of the enzyme by octyl gallate is a slow and reversible reaction without residual activity. The inhibition kinetics analyzed by Lineweaver-Burk plots indicates that octyl gallate is a competitive inhibitor, and the inhibition constant, KI, was obtained as 0.54 μM. One molecule of octyl gallate scavenged six molecules of 1,1-diphenyl-2-picrylhydrazyl and inhibited autoxidative lipid peroxidation. In addition, octyl gallate was effective in preventing lipid peroxidation.