256934-39-1

Basic information

• Product Name: (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL
• Synonyms: HU-308;(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL;4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol;(1R,4R,5R)-rel-(+)-4-[4-(1,1-DiMethylheptyl)-2,6-diMethoxyphenyl]-6,6-diMethylbicyclo[3.1.1]hept-2-ene-2-Methanol;[(1S,2S,5S)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol
• CAS NO: 256934-39-1
• Molecular Formula: C27H42O3
• Molecular Weight: 414.62
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 256934-39-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 508.668 °C at 760 mmHg
• Flash Point: 261.433 °C
• Appearance: /
• Density: 0.999
• Storage Temp.: Store at -20°C
• Solubility: Soluble in DMSO
• PKA: 14.77±0.10(Predicted)
• CAS DataBase Reference: (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL(256934-39-1)
• EPA Substance Registry System: (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL(256934-39-1)

Safety Data

• Hazardous Substances Data: 256934-39-1(Hazardous Substances Data)

Usage

Description

(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL is a complex organic compound with a unique molecular structure. It is characterized by its bicyclic framework and multiple functional groups, including dimethoxyphenyl and dimethyl moieties. (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL has potential applications in various fields due to its specific chemical properties and interactions.

Uses

1. Used in Pharmaceutical Applications:
(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL is used as a specific CB2-specific agonist for inhibiting forskolin-stimulated cAMP production in CB2-transfected cells. Its ability to reduce blood pressure, block defecation, and elicit anti-inflammatory and peripheral analgesic activity makes it a promising candidate for the development of new therapies for hypertension, inflammation, and pain.
2. Used in Controlled Substances:
As a controlled substance, (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL may have regulatory restrictions on its production, distribution, and use. This classification could be due to its potential for abuse or its use in the synthesis of other controlled substances.
Please note that the provided materials do not mention any specific application industry or reason for the use of (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL. The uses listed above are inferred from the general properties and potential applications of similar compounds.

Biological Activity

Potent and selective CB 2 receptor agonist (K i values are 22.7 nM and > 10 μ M for CB 2 and CB 1 receptors respectively, EC 50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain.

Upstream product

• 1220887-85-3 2-(3-myrtenyl-pivalate)-5-dimethylheptyl dimethylresorcinol 
• 113473-32-8 [(1S,5R)-6,6-dimethyl-4-oxobicyclo[3.1.1]hept-2-en-2-yl]methyl 2,2-dimethylpropanoate 
• 113473-31-7 [(1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl 2,2-dimethylpropanoate 
• 6712-78-3 myrtenol 
• 7785-70-8 (+)-α-pinene 
• 76163-81-0 2,2-Dimethyl-propionic acid (1S,4S,5S)-4-[4-(1,1-dimethyl-heptyl)-2,6-dihydroxy-phenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-ylmethyl ester 
• 926645-58-1 [(1S,5R)-4-hydroxy-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl 2,2-dimethylpropanoate 

Relevant articles and documents

METHODS, PROCESSES, AND COMPOSITIONS FOR IMPROVED PREPARATION OF HU308 AND HU433

Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.