25755-85-5

Basic information

• Product Name: 3-(4-CHLOROPHENYL)-5(4H)-ISOXAZOLONE
• Synonyms: 3-(4-CHLOROPHENYL)-5(4H)-ISOXAZOLONE
• CAS NO: 25755-85-5
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.60244
• Mol File: 25755-85-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)-5(4H)-ISOXAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)-5(4H)-ISOXAZOLONE(25755-85-5)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)-5(4H)-ISOXAZOLONE(25755-85-5)

Safety Data

• Hazardous Substances Data: 25755-85-5(Hazardous Substances Data)

Usage

Physical appearance

white to off-white crystalline powder

Common use

pesticide or herbicide

Mode of action

inhibits plant growth by disrupting protein synthesis

Regulatory status

heavily regulated due to toxicity and environmental impact

Upstream product

• 124-38-9 carbon dioxide 
• 1956-39-4 4-chloroacetophenone oxime 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 99-91-2 para-chloroacetophenone 
• 22027-53-8 methyl 3-(4-chlorophenyl)-3-oxopropanoate 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 25755-86-6 3-(4-chlorophenyl)-5-methoxyisoxazole 
• 64300-30-7 3-(4-chloro-phenyl)-5-ethoxy-isoxazole 
• 53314-17-3 2-(4-chlorophenyl)-5-methyl-1H-benzo[d]imidazole 
• 139436-62-7 2-(4-Chloro-phenyl)-6-methyl-quinoxaline 
• 1792-41-2 2,5-dimethylbenzimidazole 
• 142335-31-7 4-(4-Chloro-phenyl)-7-methyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 69498-30-2 5-chloro-2-(4-chlorophenyl)-1H-benzo[d]imidazole 
• 139436-66-1 6-chloro-2-(4-chlorophenyl)quinoxaline 
• 2818-69-1 5-chloro-2-methyl-1H-benzimidazole 
• 142335-35-1 7-Chloro-4-(4-chloro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one 

Relevant articles and documents

Construction of isoxazolone-fused phenanthridinesviaRh-catalyzed cascade C-H activation/cyclization of 3-arylisoxazolones with cyclic 2-diazo-1,3-diketones

A Rh(iii)-catalyzed cascade C-H activation/intramolecular cyclization of 3-aryl-5-isoxazolones with cyclic 2-diazo-1,3-diketones was described, leading to the formation of isoxazolo[2,3-f]phenanthridine skeletons. The protocol features the simultaneous one-pot formation of two new C-C/C-N bonds and one heterocycle in moderate-to-good yields with good functional group compatibility. It is amenable to large-scale synthesis and further transformation.

Atom-Economic Silver-Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones

An unprecedented silver-catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom-economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late-stage modification of a few biologically active molecules.

Base initiated aromatization/CO bond formation: A new entry to O-pyrazole polyfluoroarylated ethers

A base initiated intermolecular SNAr reaction of pyrazolones with polyfluoroarenes was developed. The process involved the isomerization aromatization of pyrazolone followed by the CO bond formation via the selective CF bond cleavage. With this strategy, a wide range of O-pyrazole polyfluoroarylated ethers bearing diverse functional groups were synthesized in mild to good yields. Additionally, our method was also applied to the isoxazol substrates.