257628-68-5Relevant articles and documents
Tunable Synthesis of α-Amino Boronic Esters from Available Aldehydes and Amines through Sequential One-Pot Dehydration and Copper-Catalyzed Borylacylation
Xia, Qi,Chang, Hua-Rong,Li, Juan,Wang, Jia-Yi,Peng, Yan-Qing,Song, Gong-Hua
, p. 2716 - 2724 (2020/01/31)
Copper-catalyzed multicomponent borylacylation of imines with acid chlorides and bis(pinacolato)diboron was developed for the preparation of synthetically useful and pharmacologically relevant α-amino boronic acid derivatives. Starting from a range of acid chlorides and imines with aryl, heteroaryl, and alkyl substituents, most of these ligand-free reactions proceeded smoothly at room temperature in moderate to good yields. Furthermore, a facile and convenient one-pot, multistep access to the direct synthesis of α-amino boronic acid derivatives from available aldehydes and amines was also developed.
Regioselective Cu(I)-catalyzed tandem A3-coupling/ decarboxylative coupling to 3-amino-1,4-enynes
Feng, Huangdi,Ermolat'Ev, Denis S.,Song, Gonghua,Van Der Eycken, Erik V.
supporting information; experimental part, p. 1942 - 1945 (2012/05/31)
An efficient and novel copper-mediated protocol for the synthesis of 3-amino-1,4-enynes from glyoxylic acid, an amine, and an alkyne was developed. This new reaction involving two sequential C-C bond formations is air and moisture tolerant and proceeds via a tandem A3-coupling and a selective decarboxylative coupling.
COMPOUNDS FOR IMPROVING LEARNING AND MEMORY
-
Page/Page column 3; 19, (2009/12/23)
The present invention provides a compound of Formula I: (I) and methods for improving memory in a subject by administering a therapeutically effective amount of the compound.