25808-30-4

Basic information

• Product Name: Methylaminoacetonitrile hydrochloride
• Synonyms: MethylaMinoacetonitrile Hydrochloride, 97+%;(methylamino)-acetonitrilmonohydrochloride;SARCOSINE NITRILE HYDROCHLORIDE;SARCOSINITRILE;SARCOSINITRILE HYDROCHLORIDE;ACETONITRILE, (METHYLAMINO)-, MONOHYDROCHLORIDE;METHYLAMINOACETONITRILE HCL;METHYLAMINOACETONITRILE HYDROCHLORIDE
• CAS NO: 25808-30-4
• Molecular Formula: C₃H₆N₂*ClH
• Molecular Weight: 106.55
• EINECS: 247-277-6
• Product Categories: Anthraquinones, Hydroquinones and Quinones;Building Blocks;C1 to C5;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks
• Mol File: 25808-30-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 103-106 °C(lit.)
• Boiling Point: 150.2ºC at 760 mmHg
• Flash Point: 44.6ºC
• Appearance: /
• Vapor Pressure: 3.89mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 3908975
• CAS DataBase Reference: Methylaminoacetonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methylaminoacetonitrile hydrochloride(25808-30-4)
• EPA Substance Registry System: Methylaminoacetonitrile hydrochloride(25808-30-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 25808-30-4(Hazardous Substances Data)

Usage

Description

Methylaminoacetonitrile hydrochloride is a yellow crystalline compound that serves as an essential intermediate in the pharmaceutical and chemical synthesis industries. It is notably recognized as the primary raw material for the preparation of tadalafil, a medication approved by the FDA in 2003 for the treatment of erectile dysfunction in men.

Uses

Used in Pharmaceutical Industry:
Methylaminoacetonitrile hydrochloride is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its primary application is in the production of tadalafil, a drug prescribed for the treatment of erectile dysfunction in men. Tadalafil works by enhancing the effects of nitric oxide in the body, which leads to the widening of blood vessels and improved blood flow to the penis, thus facilitating an erection.
Used in Chemical Synthesis:
In the chemical synthesis industry, methylaminoacetonitrile hydrochloride is utilized as a building block for the creation of various chemical compounds. Its unique structure and properties make it a valuable component in the development of new and innovative products, contributing to the advancement of the chemical synthesis field.
Overall, methylaminoacetonitrile hydrochloride plays a significant role in both the pharmaceutical and chemical synthesis industries, primarily due to its use in the production of tadalafil and its potential applications in the development of new chemical compounds.

InChI:InChI=1/C3H6N2.ClH/c1-5-3-2-4;/h5H,3H2,1H3;1H

Downstream Products

• 40511-15-7 1-(3,4-dimethoxy-phenyl)-2-methylamino-ethanone; hydrochloride 
• 117712-19-3 1-(4-methoxy-phenyl)-2-methylamino-ethanone 
• 29705-82-6 1-(2,4-dihydroxy-phenyl)-2-methylamino-ethanone; hydrochloride 
• 21213-89-8 1-(4-hydroxy-phenyl)-2-methylamino-ethanone 
• 339363-03-0 N'-cyano-N-(cyanomethyl)-N-methylacetimidamide 
• 136262-88-9 (Cyanomethyl-methyl-amino)-o-tolyl-acetonitrile 
• 168542-76-5 N-(cyanomethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide 
• 22985-07-5 2,4-dichloro-N-cyanomethyl-N-methyl-3,5-dinitrobenzamide 
• 168541-96-6 N-(cyanomethyl)-3-(4-fluorobenzoyl)-N-methyl-2-pyridinecarboxamide 
• 29705-80-4 1-(4-methoxyphenyl)-2-(methylamino)ethan-1-one hydrochloride 
• 135737-05-2 (4-Chloro-phenyl)-(cyanomethyl-methyl-amino)-acetonitrile 
• 35118-28-6 N-Cyanomethyl-N-methyl-2-nitro-benzamide 
• 3684-97-7 N-nitrosomethylaminoacetonitrile 

Relevant articles and documents

METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS

The invention features a method for treating chronic pain using a compound selected from formulae (I), (II)A, (I)B and (I)C.