2582-30-1

Basic information

• Product Name: Aminoguanidine bicarbonate
• Synonyms: Aminoguanidine bicarbonate ;Aminoguanidine hydrogen carbonate;AMINOGUANIDINE BICARBONATE CRYSTALLINE;1-AMINOGUANIDINIUM HYDROGEN CARBONATE OE;Aminoguanidine bicarbonate, 98.50%;Carbonic acid, compd. with hydrazinecarboximidamide (1:1);guanylhydrazine bicarbonate salt;CARBONICACID,COMPDWITHHYDRAZINECARBOXIMIDAMIDE;Aminoguanidinbicarbonat
• CAS NO: 2582-30-1
• Molecular Formula: CHO₃*CH₇N₄
• Molecular Weight: 136.11
• EINECS: 219-956-7
• Product Categories: Pharmaceutical Intermediates;white powder
• Mol File: 2582-30-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 170-172 °C (dec.)(lit.)
• Boiling Point: 422.4 °C at 760 mmHg
• Flash Point: 209.3 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 1,6 g/cm3
• Vapor Pressure: 2.56E-08mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: H2O: soluble2.7g/L at 20°C
• PKA: 6.19[at 20 ℃]
• Water Solubility: <5 g/L (20℃)
• BRN: 3569869
• CAS DataBase Reference: Aminoguanidine bicarbonate(CAS DataBase Reference)
• NIST Chemistry Reference: Aminoguanidine bicarbonate(2582-30-1)
• EPA Substance Registry System: Aminoguanidine bicarbonate(2582-30-1)

Safety Data

• Hazard Codes: Xi,Xn,N
• Statements: 52/53-43-36/37/38-20/21/22-51/53
• Safety Statements: 22-24/25-37-24-36-26-36/37
• RIDADR: UN3077
• WGK Germany: 2
• RTECS: FG1772000
• TSCA: Yes
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 2582-30-1(Hazardous Substances Data)

Usage

Description

Aminoguanidine bicarbonate (AGB) is a white to off-white crystalline powder that is almost insoluble in water, alcohol, and other acids. It is a compound of practical importance due to its various applications in different industries and its role in the synthesis of various pharmaceutical agents.

Uses

Used in Dyes and Dispersants Industry:
Aminoguanidine bicarbonate is used as a chemical intermediate for the production of dyes and dispersants, contributing to the enhancement of color and dispersion properties in these applications.
Used in Explosives Industry:
AGB is utilized as a component in the manufacturing of explosives, where its chemical properties play a crucial role in the performance and stability of the final product.
Used in Pharmaceutical Industry Antitumor and Antileukemic Agents:
Aminoguanidine bicarbonate is used as a key compound in the synthesis of antitumor and antileukemic agents, targeting cancer cells and aiding in the development of treatments for various types of cancer.
Used in Pharmaceutical Industry Neuraminidase Inhibitors:
AGB is also employed in the synthesis of neuraminidase inhibitors, which are essential in the inhibition of influenza, helping to combat the spread of the virus and alleviate its symptoms.
Used in Research Nitric Oxide Synthase (NOS) Inhibition:
Aminoguanidine bicarbonate is used as an inhibitor of NOS in research studies, particularly to investigate the effects of polyamines on rat embryo cell cultures infected with adenovirus type 5, providing valuable insights into the role of NOS in various biological processes.

Biochem/physiol Actions

Aminoguanidine bicarbonate protects the cells infected with adenovirus from chromosomal damage. Aminoguanidine is a specific and highly effective inhibitor of diamine oxidase present in fetal calf serum.

Synthesis

A synthesis method of aminoguanidine bicarbonate includes reacting an acidic aqueous hydrazine hydrate solution with calcium cyanamide in an elevated temperature to produce an aminoguanidine solution, recovering the solution, and reacting therewith an alkali metal bicarbonate to produce relatively high purity aminoguanidine bicarbonate.

InChI:InChI=1/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)/p-2

Upstream product

• 133082-93-6 aminoguanidine hydroiodide 
• 298-14-6 potassium hydrogencarbonate 
• 1068-42-4 aminoguanidine hemisulfate salt 
• 420-04-2 CYANAMID 
• 124-38-9 carbon dioxide 
• 556-88-7 nitroguanidine 

Downstream Products

• 1945-68-2 1,1'-(Aethylaethandiylidendinitrilo)-diguanidin 
• 18730-12-6 1-(4-Chlor-2-acetamido-benzamido)-guanidin 
• 23817-71-2 C₈H₈ClN₅O₂ 
• 19992-91-7 4-Fluor-benzophenon-guanylhydrazon 
• 23817-55-2 C₈H₅F₅N₄ 
• 23817-66-5 2,4-dinitrobenzaldehyde guanylhydrazone 
• 23817-61-0 C₈H₉N₅O₃ 
• 23817-58-5 C₁₃H₂₀N₄O₂ 
• 46388-73-2 3-Hydroxy-guanabenz 
• 4364-74-3 2-cyclohexylidene-1-hydrazinecarboximidamide 
• 1945-65-9 1,4-Diformyl-benzol-di-guanylhydrazon 
• 23817-68-7 C₁₀H₁₃N₅O₄ 
• 23140-10-5 methyl-[1,4]benzoquinone-bis-carbamimidoylhydrazone 
• 46322-66-1 2,4-dichlorobenzaldehyde guanylhydrazone 

Relevant articles and documents

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Aminoguanidine bicarbonate with particular properties and method for making same

The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine in the presence of CO2. The invention is characterised in that it consists in proceeding with an amount of cyamide slightly higher than the stoichiometric quantity. The invention also concerns quasi-spherical agglomerates of aminoguanidine bicarbonate crystals.

Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole

A method for producing 3-amino-5-mercapto-1,2,4-triazole, useful as an intermediate compound for a medicine or pesticide, or the intermediate thereof, a salt of N-guanidino thiourea from aminoguanidine thiocyanate or a thiocyanate and an aminoguanidine compound in the presence of an acid in a polar solvent, or even from hydrazine and cyanamide is disclosed.