258338-12-4

Basic information

• Product Name: GHRELIN (RAT)
• Synonyms: H-GLY-SER-SER(OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;H-GLY-SER-SER(OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-LYS-ALA-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;H-GLY-SER-[SER(N-OCTANOYL)]-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;GHRELIN (RAT);GHRELIN, RAT, SER(N-OCTANOYL);GHRELIN (RAT) TRIFLUOROACETATE;GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-LYS-ALA-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-LYS-ALA-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG
• CAS NO: 258338-12-4
• Molecular Formula: C147H245N45O42
• Molecular Weight: 3314.79
• Product Categories: Peptide;GH-RHObesity Research;GH-RHPeptides for Cell Biology;Growth Hormone Releasing Factors;Neuropeptides;Neurotransmission (Obesity);Releasing Factors;Ghrelin receptor;Peptide Receptors;proteins
• Mol File: 258338-12-4.mol
• Article Data: 0

Chemical Properties

• Appearance: Solid
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• CAS DataBase Reference: GHRELIN (RAT)(CAS DataBase Reference)
• NIST Chemistry Reference: GHRELIN (RAT)(258338-12-4)
• EPA Substance Registry System: GHRELIN (RAT)(258338-12-4)

Safety Data

• WGK Germany: 3
• RTECS: LY8965000
• Hazardous Substances Data: 258338-12-4(Hazardous Substances Data)

Usage

Description

Ghrelin (RAT), also known as the growth hormone secretagogue receptor ligand, is a 28-amino acid peptide that plays a crucial role in hunger signaling and is predominantly synthesized in the stomach. It is also produced by a specific subset of hypothalamic neurons and is found in various tissues, including the gastrointestinal tract, hypothalamic arcuate nucleus, pituitary, kidney, liver, heart, lung, and adipose tissue. The Ser3 residue of this peptide is N-octanoylated, which is essential for its biological activity.

Uses

Used in Pharmaceutical Research:
Ghrelin (RAT) is used as a research compound for studying its effects on various physiological processes and conditions. It is particularly useful in understanding the role of ghrelin in hunger signaling, growth hormone secretion, and energy balance regulation.
Used in Neuroscience Research:
Ghrelin (RAT) is used as a neurochemical agent for investigating its influence on cognitive functions, such as passive avoidance learning (PAV) and spatial learning. It is also used to study the effects of ghrelin on penicillin-induced epileptiform activity in rats, which can provide insights into the role of ghrelin in neurological disorders.
Used in Gastroenterology Research:
Ghrelin (RAT) is used as a gastrointestinal agent for examining its effects on celiac disease and other gastrointestinal conditions. This research can help in understanding the role of ghrelin in gut-brain communication and its potential therapeutic applications in gastrointestinal disorders.
Used in Endocrinology Research:
Ghrelin (RAT) is used as an endocrine agent for studying its role in the regulation of growth hormone secretion and energy balance. This research can contribute to the development of novel therapeutic strategies for conditions related to growth hormone deficiency or obesity.

Biochem/physiol Actions

Ghrelin acts as a ligand for G-protein coupled receptor, GHS-R1A (growth hormone secretagogue receptor), and controls energy utilization and feeding. This peptide is involved in enhancing the value of rewarding foods, drugs and alcohol. In rats with diabetes, the expression of ghrelin increased as a result of cachexia. In rats with ovariectomy, the expression of this peptide decreased in the endometrium. This peptide controls cognitive functions and has neuroprotective roles in neurodegenerative disorders. In cultured cortical neuronal networks, ghrelin increases the rate of synapse formation and activity development.