2584-37-4

Basic information

• Product Name: 1-METHYL-4-PHENYL-1H-QUINOLIN-2-ONE
• Synonyms: 1-METHYL-4-PHENYL-1H-QUINOLIN-2-ONE;RARECHEM AQ NN 0206
• CAS NO: 2584-37-4
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.28
• Mol File: 2584-37-4.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-METHYL-4-PHENYL-1H-QUINOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-PHENYL-1H-QUINOLIN-2-ONE(2584-37-4)
• EPA Substance Registry System: 1-METHYL-4-PHENYL-1H-QUINOLIN-2-ONE(2584-37-4)

Safety Data

• Hazardous Substances Data: 2584-37-4(Hazardous Substances Data)

Usage

Type of compound

Quinolinone derivative

Usage

Research as a biochemical tool or in the synthesis of other compounds

Pharmacological properties

Potential antidepressant, anxiolytic agent, and neuroprotective effects; potential role in treating neurodegenerative diseases

Other properties

Antioxidant properties; interest for studying oxidative stress and related pathways in biological systems

Interest

Therapeutic and research applications in neuroscience and pharmacology.

Upstream product

• 7664-93-9 sulfuric acid 
• 2665-92-1 N-methyl-3-oxo-N,3-diphenylpropanamide 
• 94298-51-8 N-methyl-N,3-diphenylprop-2-ynamide 
• 696-62-8 para-iodoanisole 
• 178215-64-0 1-methyl-2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid 
• 81698-18-2 ethyl 1-methyl-2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylate 
• 1859-76-3 2-(methylamino)benzophenone 
• 64097-92-3 2-(1-phenylvinyl)aniline 
• 30752-15-9 5-methyl-2-phenylbenzo[b][1,4]thiazepin-4(5H)-one 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 62-53-3 aniline 
• 959-66-0 3-oxo-3-phenylpropionanilide 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 852203-12-4 3-bromo-1-methyl-4-phenylquinolin-2(1H)-one 
• 852203-14-6 6-bromo-1-methyl-4-phenylquinolin-2(1H)-one 

Relevant articles and documents

Reversibility in Lewis-acid promoted reactions of N-arylcinnamamides

The Lewis-acid promoted cyclisation reactions of N-arylcinnamamides have been investigated. With aluminium chloride a range of products were obtained, while much more selective cyclisation reactions were observed with bismuth chloride.

Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones

Direct enantioselective hydrogenation of unsaturated compounds to generate chiral three-dimensional motifs is one of the most straightforward and important approaches in synthetic chemistry. We realized the Ru(II)-NHC-catalyzed asymmetric hydrogenation of 2-quinolones under mild reaction conditions. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones were obtained in high yields with moderate to excellent enantioselectivities. The reaction provides an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.

Lactamization of sp2C?H Bonds with CO2: Transition-Metal-Free and Redox-Neutral

The first direct use of carbon dioxide in the lactamization of alkenyl and heteroaryl C?H bonds to synthesize important 2-quinolinones and polyheterocycles in moderate to excellent yields is reported. Carbon dioxide, a nontoxic, inexpensive, and readily available greenhouse gas, acts as an ideal carbonyl source. Importantly, this transition-metal-free and redox-neutral process is eco-friendly and desirable for the pharmaceutical industry. Moreover, these reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.