25844-72-8

Basic information

• Product Name: 5-PHENYL-1H-PYRAZIN-2-ONE
• Synonyms: 5-PHENYL-1H-PYRAZIN-2-ONE;5-Phenylpyrazin-2(1H)-one;5-phenyl-1,2-dihydropyrazin-2-one
• CAS NO: 25844-72-8
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Mol File: 25844-72-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 473.4°Cat760mmHg
• Flash Point: 240.1°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 1.39E-09mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 5-PHENYL-1H-PYRAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-1H-PYRAZIN-2-ONE(25844-72-8)
• EPA Substance Registry System: 5-PHENYL-1H-PYRAZIN-2-ONE(25844-72-8)

Safety Data

• Hazardous Substances Data: 25844-72-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8N2O/c13-10-7-11-9(6-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 1668-10-6 glycinamide hydrochloride 
• 160315-13-9 2-acetoxy-5-phenylpyrazine 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 25844-73-9 2-Chloro-5-phenyl-pyrazine 
• 78146-52-8 phenylglyoxal monohydrate 
• 29460-97-7 2-phenylpyrazine 
• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 

Downstream Products

• 25844-73-9 2-Chloro-5-phenyl-pyrazine 
• 105759-05-5 5-phenylpyrazine-2-thiol 
• 78174-96-6 5-Methyl-8-phenyl-2,3-dioxa-5,7-diaza-bicyclo[2.2.2]oct-7-en-6-one 
• 32493-80-4 2,3-dichloro-5-phenylpyrazine 
• 64163-13-9 1-hydroxy-5-phenyl-2(1H)-pyrazinone 
• 76849-81-5 2-hydroxy-5-phenylpyrazine 4-oxide 
• 85093-95-4 3,5-dichloro-2-phenylpyrazine 1-oxide 
• 85093-93-2 2-chloro-5-phenylpyrazine 1,4-dioxide 
• 61578-12-9 2-chloro-5-phenyl-pyrazine 4-oxide 
• 61578-11-8 2-chloro-5-phenylpyrazine-1-oxide 
• 64163-11-7 2,6-dichloro-3-phenylpyrazine 
• 78174-93-3 1-methyl-5-phenylpyrazin-2(1H)-one 
• 86731-84-2 3-methyl-5-phenyl-1H-pyrazin-2-one 
• 849199-45-7 1-(4-methoxybenzyl)-5-phenylpyrazin-2(1H)-one 

Relevant articles and documents

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.

HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention aims to provide a compound having a PDE inhibitory action and useful as a medicament for the prophylaxis or treatment of schizophrenia and the like. A compound represented by the formula (1x): wherein each symbol is as des

Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates

This disclosure describes novel 5-,6- and 8-(phenyl and substituted phenyl)-1,2,4-triazolo[4,3-a]pyrazines which posses utility as anxiolytic agents.