258871-60-2

Basic information

• Product Name: (-)-PF₁₁₆₃B
• CAS NO: 258871-60-2
• Molecular Weight: 461.642
• Mol File: 258871-60-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (-)-PF₁₁₆₃B(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-PF₁₁₆₃B(258871-60-2)
• EPA Substance Registry System: (-)-PF₁₁₆₃B(258871-60-2)

Safety Data

• Hazardous Substances Data: 258871-60-2(Hazardous Substances Data)

Usage

Description

(-)-PF₁₁₆₃B is a pyrazolobenzodiazepine chemical compound that functions as a potent and selective antagonist for the neuropeptide Y (NPY) Y2 receptor. This receptor plays a crucial role in the regulation of feeding behavior and energy homeostasis. (-)-PF₁₁₆₃B has demonstrated promising results in preclinical studies for its potential as a treatment for obesity and metabolic disorders, as well as for its anxiolytic and antidepressant effects, making it a candidate for psychiatric disorder treatments.

Uses

Used in Pharmaceutical Industry:
(-)-PF₁₁₆₃B is used as a potential treatment for obesity and metabolic disorders due to its ability to target the NPY Y2 receptor, which is involved in the regulation of feeding behavior and energy homeostasis.
Used in Psychiatric Disorder Treatment:
(-)-PF₁₁₆₃B is used as a potential candidate for the treatment of psychiatric disorders, such as anxiety and depression, due to its anxiolytic and antidepressant effects.
Used in Research and Development:
(-)-PF₁₁₆₃B is used as a valuable tool for further research into the NPY system and potential therapeutic applications, given its favorable pharmacokinetic properties and selectivity for the NPY Y2 receptor.

Upstream product

• 259738-79-9 (6R,9R)-9-Hydroxy-6-methyl-tetradecanoic acid tert-butyl ester 
• 259738-72-2 2-(tert-butoxycarbonyl-methyl-amino)-3-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenyl}-propionic acid 
• 66-25-1 hexanal 
• 1388220-73-2 (S)-methyl 2-[tert-butoxycarbonyl(methyl)amino]-3-[4-(2-hydroxyethoxy)phenyl]propanoate 
• 626242-99-7 3-[4-(2-benzyloxy-ethoxy)-phenyl]-2-(tert-butoxycarbonyl-methyl-amino)-propionic acid methyl ester 
• 626242-98-6 methyl 3-(4-(2-(benzyloxy)ethoxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate 
• 259738-77-7 (6R,9S)-9-(Diethyl-isopropyl-silanyloxy)-6-methyl-dodec-11-enoic acid tert-butyl ester 
• 259738-78-8 (6R,9S)-9-(Diethyl-isopropyl-silanyloxy)-6-methyl-11-oxo-undecanoic acid tert-butyl ester 
• 259738-76-6 (6R,9S)-9-Hydroxy-6-methyl-dodec-11-enoic acid tert-butyl ester 
• 259738-73-3 (E)-(R)-8-Hydroxy-6-methyl-oct-2-enoic acid tert-butyl ester 
• 259738-75-5 6-methyl-9-oxo-nonanoic acid tert-butyl ester 
• 259738-74-4 6-methyl-8-oxo-octanoic acid tert-butyl ester 
• 155005-10-0 tert-butyl (6R)-8-hydroxy-6-methyloctanoate 
• 3978-80-1 Boc-Tyr-OH 

Relevant articles and documents

Total Synthesis of PF1163B

A total synthesis of PF1163B has been achieved. The vinylogous Mukaiyama aldol reaction of ketene silyl N, O -acetal 6 (ent - 6) mediated by excess TiCl 4 proceeded with saturated aldehydes to give adduct 10 in moderate yield with moderate ster