259170-03-1 Usage
General Description
The chemical 2-(3,4-DIMETHOXYBENZYL)-3-(N-BENZYL-4-PIPERIDINE)PROPIONIC ACID, also known as donepezil intermediate, is a key building block in the synthesis of the Alzheimer's drug donepezil. It is a propionic acid derivative with a benzyl and piperidine moiety, which are important structural components for its biological activity. This intermediate is used in the production of donepezil to inhibit the enzyme acetylcholinesterase, thereby increasing the levels of the neurotransmitter acetylcholine in the brain and improving cognitive function in patients with Alzheimer's disease. Its synthesis involves several chemical reactions and purification steps to obtain the pure intermediate for further conversion into the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 259170-03-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,9,1,7 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 259170-03:
(8*2)+(7*5)+(6*9)+(5*1)+(4*7)+(3*0)+(2*0)+(1*3)=141
141 % 10 = 1
So 259170-03-1 is a valid CAS Registry Number.
259170-03-1Relevant articles and documents
Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?
Tanaka, Nao,Usuki, Toyonobu
, p. 5514 - 5522 (2020/07/24)
Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1–100 molpercent) with H2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 molpercent Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept?).
