259214-70-5

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-
• CAS NO: 259214-70-5
• Molecular Formula: C27H30N2O6
• Molecular Weight: 478.545
• Mol File: 259214-70-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(259214-70-5)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(259214-70-5)

Safety Data

• Hazardous Substances Data: 259214-70-5(Hazardous Substances Data)

Upstream product

• 20430-72-2 7-methoxy-2-phenylquinolin-4-ol 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 536-90-3 m-Anisidine 

Relevant articles and documents

ANTIVIRAL PHOSPHINATE COMPOUNDS

The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Potent inhibitors of the hepatitis C virus NS3 protease: Design and synthesis of macrocyclic substrate-based β-strand mimics

The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. The design and synthesis of 15-membered ring β-strand mimics which are capable of inhibiting the interactions between the HCV NS3 protease enzyme and its polyprotein substrate will be described. The binding interactions between a macrocyclic ligand and the enzyme were explored by NMR and molecular dynamics, and a model of the ligand/enzyme complex was developed.