259269-84-6Relevant articles and documents
Amide derivative and preparation method and application thereof
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Paragraph 0058-0065, (2019/10/23)
The invention relates to an amide derivative and a preparation method and application thereof. The compound is an amide derivative containing 3-bromo-5-chloro (bromo) phenyl units, has obvious insecticidal activity, and can be used for killing various bio
FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF
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Paragraph 0502-0503, (2018/08/12)
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.
Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring
Barlaam, Bernard,Harris, Craig S.,Lecoq, Jonathan,Nguyen, Ha Thi Hoang
experimental part, p. 534 - 543 (2012/01/06)
The preparation of 6-aminoquinazolin-4(3H)-ones requires the use of platinum-metal group catalysis on the corresponding C-6-iodo or 6-bromo precursors. Herein, we report to our knowledge the first successful S NAr reaction directly at the unact