259807-95-9

Basic information

• Product Name: 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE
• Synonyms: 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE;2-Methyl-6-(tri-n-butylstannyl)pyridine, 96%;(6-Methylpyridin-2-yl)tributylstannane;(6-Methylpyridin-2-yl)tributylstannane, 6-(Tributylstannyl)-2-picoline;2-(Tributylstannyl)-6-Methylpyridine;2-Methyl-6-tributylstannanylpyridine
• CAS NO: 259807-95-9
• Molecular Formula: C₁₈H₃₃NSn
• Molecular Weight: 382.17
• Product Categories: Stannanes
• Mol File: 259807-95-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 391.861°C at 760 mmHg
• Flash Point: 87℃
• Appearance: /
• Density: 1.134 g/mL at 25 °C
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: n20/D1.512
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.92±0.19(Predicted)
• CAS DataBase Reference: 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE(259807-95-9)
• EPA Substance Registry System: 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE(259807-95-9)

Safety Data

• Hazard Codes: T,N
• Statements: 21-25-36/38-48/23/25-50/53
• Safety Statements: 36/37/39-45-60-61
• RIDADR: UN 2788 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 259807-95-9(Hazardous Substances Data)

Usage

General Description

6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE is a chemical compound with the molecular formula C16H27N Sn. It is a stannylated pyridine derivative that contains a methyl group at the 6-position of the pyridine ring and three tributylstannyl groups attached to the 2-position. 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE is commonly used as a reagent in organic synthesis, particularly in the functionalization of aromatic compounds. The tributylstannyl group can serve as a leaving group in various reactions, making 6-METHYL-2-(TRIBUTYLSTANNYL)PYRIDINE a versatile tool in the synthesis of complex organic molecules. Additionally, it is important to handle this compound with caution as it is toxic and can cause harmful effects if not used properly.

InChI:InChI=1/C6H6N.3C4H9.Sn/c1-6-4-2-3-5-7-6;3*1-3-4-2;/h2-4H,1H3;3*1,3-4H2,2H3;/rC18H33NSn/c1-5-8-14-20(15-9-6-2,16-10-7-3)18-13-11-12-17(4)19-18/h11-13H,5-10,14-16H2,1-4H3

Upstream product

• 1461-22-9 tributyltin chloride 
• 5315-25-3 2-bromo-6-methylpyridine 
• 688-73-3 tri-n-butyl-tin hydride 
• 4226-01-1 tri-n-butyltin lithium 
• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 316800-48-3 6,4',6''-trimethyl-[2,2';6',2'']terpyridine 
• 372520-84-8 6,6''-dimethyl-2,2':6',2''-terpyridine-4'-carboxylic acid ethyl ester 
• 485815-52-9 ethyl 6-bromo-6'-methyl-4-(2,2'-bipyridine)carboxylate 
• 853298-67-6 3-(6-methyl-pyridin-2-yl)-5-trifluoromethyl-phenylamine 
• 56100-22-2 6-methyl-2,2'-bipyridine 
• 853298-66-5 1-[4-(6-amino-pyrimidin-4-yloxy)-phenyl]-3-[3-(6-methyl-pyridin-2-yl)-5-trifluoromethyl-phenyl]-urea 
• 158666-42-3 4-carbomethoxy-6,6'-bis(bromomethyl)-2,2'-bipyridine 
• 1402034-36-9 6,6’-(1,10-phenanthrolin-2,9-diyl)-2,2’-di(N-hexyl-N-phenyl)picolinamide 
• 1402034-35-8 6,6’-(1,10-phenanthrolin-2,9-diyl)-2,2’-di(N-ethyl-N-phenyl)picolinamide 
• 1197182-98-1 N-(2-methoxypyridin-4-ylmethyl)-4-(6-methylpyridin-2-yl)benzenesulfonamide 
• 854755-92-3 benzyl (4S,5S)-5-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl}-2,2-dimethyl-4-[4-(6-methyl-2-pyridinyl)benzyl]-1,3-oxazolidine-3-carboxylate 
• 372520-85-9 ethyl 6,6''-bis-(bromomethyl)-2,2':6',2''-terpyridine-4'-carboxylate 

Relevant articles and documents

Conformational study of an artificial metal-dependent regulation site for use in designer proteins

This report describes the dimerisation of glutathione, and by extension, other cysteine-containing peptides or protein fragments, with a 5, 5'-disubstituted-2, 2'-bipyridine or 6, 6''-disubstituted-2, 2':6',2''-terpyridine unit. The resulting bipy-GS2 and terpy-GS 2 were investigated as potential metal ion dependent switches in aqueous solution, and were found to predominantly adopt the transoid conformation at physiological pH. Metal complexation with CuII and ZnII at this pH has been studied by UV/Vis, CD, NMR and ion-mobility mass spectrometry. ZnII titrations are consistent with the formation of a 1:1 ZnII:terpy-GS2 complex at pH 7.4, but bipy-GS2 was shown to form both 1:1 and 1:2 complexes with the former being predominant under dilute micromolar conditions. Formation constants for the resulting 1:1 complexes were determined to be log KM 6.86 (bipy-GS2) and 6.22 (terpy-GS2), consistent with a higher affinity for the unconstrained bipyridine, compared to the strained terpyridine. CuII coordination involves the initial formation of 1:1 complexes, followed by 1.5Cu:1bipy-GS2 and 2Cu:1terpy-GS2 complexes at micromolar concentrations. Binding constants for formation of the 1:1 complexes (log KM 12.5 (bipy-GS2); 8.04 and 7.14 (terpy-GS2)) indicate a higher affinity for CuII than ZnII. Finally, ion-mobility MS studies detected the free ligands in their protonated form, and were consistent with the formation of two different Cu adducts with different conformations in the gas-phase. We illustrate that the bipyridine and terpyridine dimerisation units can behave like conformational switches in response to Cu/Zn complexation, and propose that in future these can be employed in synthetic biology with larger peptide or protein fragments, to control large scale folding and related biological function. Copyright

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention discloses compounds useful in treatment of conditions associated with excessive activity of transforming growth factor beta (TGF-β), particularly type 1 or activin-like kinase 5 (ALK 5). Specifically the present invention discloses compound of formula (I) which exhibit inhibitory activity against ALK 5. Method of treating conditions associated with excessive activity (ALK 5) with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Optically Active Helical Lanthanide Complexes: Storable Chiral Lewis Acidic Catalysts for Enantioselective Diels–Alder Reaction of Siloxydienes

Lanthanide triflates and a series of hexadentate chiral ligand complexes were synthesized. X-ray-quality crystals were obtained from mixtures of the lanthanide complexes, which were helical in shape. The complexes showed Lewis acidity and catalyzed the enantioselective Diels–Alder reaction of electron-rich siloxydienes. The complexes were stable enough to be stored at ambient temperature on a laboratory bench and retained their Lewis acidity even after a month.