259860-04-3

Basic information

• Product Name: 1H-Indole, 6-chloro-7-fluoro-
• Synonyms: 1H-Indole, 6-chloro-7-fluoro-;6-chloro-7-fluoro-1H-indole
• CAS NO: 259860-04-3
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.5834032
• Mol File: 259860-04-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 299.8°C at 760 mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.436g/cm³
• Vapor Pressure: 0.00208mmHg at 25°C
• Refractive Index: 1.657
• PKA: 14.65±0.30(Predicted)
• CAS DataBase Reference: 1H-Indole, 6-chloro-7-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 6-chloro-7-fluoro-(259860-04-3)
• EPA Substance Registry System: 1H-Indole, 6-chloro-7-fluoro-(259860-04-3)

Safety Data

• Hazardous Substances Data: 259860-04-3(Hazardous Substances Data)

Usage

Description

1H-Indole, 6-chloro-7-fluorois a heterocyclic organic compound that belongs to the indole derivative family. It features a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring, with a chlorine atom at the sixth position and a fluorine atom at the seventh position of the indole ring. 1H-Indole, 6-chloro-7-fluorois of interest in the field of medicinal chemistry due to its potential biological activities and applications in the development of various medications and drug candidates.

Uses

Used in Pharmaceutical Industry:
1H-Indole, 6-chloro-7-fluorois used as a key intermediate in the synthesis of various medications and drug candidates. Its unique chemical structure and potential biological activities make it a valuable compound for the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
1H-Indole, 6-chloro-7-fluorois utilized in medicinal chemistry research to explore its potential as a lead compound for the discovery of novel drugs. Its properties and interactions with biological targets can provide insights into the design and optimization of new pharmaceutical agents.
Used in Drug Development:
1H-Indole, 6-chloro-7-fluorois employed in drug development processes to create new chemical entities with potential therapeutic benefits. Its unique substitution pattern and heterocyclic nature offer opportunities for the design of innovative drug molecules with improved efficacy and selectivity.

InChI:InChI=1/C8H5ClFN/c9-6-2-1-5-3-4-11-8(5)7(6)10/h1-4,11H

Upstream product

• 1816-92-8 Methyl azidoacetate 
• 5527-95-7 4-chloro-3-fluorobenzaldehyde 
• 259860-07-6 6-chloro-7-fluoroindole-2-carboxylic acid 
• 259860-06-5 methyl 6-chloro-7-fluoroindole-2-carboxylate 
• 467456-99-1 1-(2-amino-4-chloro-3-fluorophenyl)-2-chloroethan-1-one 
• 2106-04-9 3-chloro-2-fluoroaniline 
• 2106-49-2 1-chloro-2-fluoro-3-nitrobenzene 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 1782070-22-7 3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl)thio)-2-fluorobenzoic acid 

Relevant articles and documents

SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES

The present application relates to alkoxy-substituted pyridinyl indolsulfonamides. The compounds are negative GPR17 modulators and have utility in the treatment of various GPR17 associated disorders.

(AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES

Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR

The present invention relates to the use compounds of formula I which are antagonists of the 5-HT 6 receptor, for treating a cognitive disorder selected from the group consisting of age-related cognitive decline, mild cognitive impairment and dementia