25991-27-9 Usage
Description
3-CARBOMETHOXY-2-PYRONE, also known as Methyl 2-oxo-2H-pyran-3-carboxylate, is a cyclic α,β-unsaturated ketone characterized by its light yellow crystalline solid appearance. It is known for its ability to weakly activate caspases-3, -8, and -9 in HL-60 cells.
Uses
Used in Pharmaceutical Research:
3-CARBOMETHOXY-2-PYRONE is used as a reagent for investigating α,β-unsaturated carbonyl compounds for their cytotoxic profiles against oral human normal and tumor cells. This application aids in the discovery and development of potential therapeutic agents for various diseases, including cancer.
Used in Biochemical Studies:
In biochemical research, 3-CARBOMETHOXY-2-PYRONE serves as a valuable tool for understanding the mechanisms of action and interactions of α,β-unsaturated carbonyl compounds with cellular components, particularly in the context of their cytotoxic effects on oral human cells.
Check Digit Verification of cas no
The CAS Registry Mumber 25991-27-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,9,9 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 25991-27:
(7*2)+(6*5)+(5*9)+(4*9)+(3*1)+(2*2)+(1*7)=139
139 % 10 = 9
So 25991-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O4/c1-10-6(8)5-3-2-4-11-7(5)9/h2-4H,1H3
25991-27-9Relevant articles and documents
Enantioselective Synthesis of Arene cis-Dihydrodiols from 2-Pyrones
Liang, Xiao-Wei,Zhao, Yunlong,Si, Xu-Ge,Xu, Meng-Meng,Tan, Jia-Hao,Zhang, Zhi-Mao,Zheng, Cheng-Gong,Zheng, Chao,Cai, Quan
supporting information, p. 14562 - 14567 (2019/09/06)
An enantioselective chemical synthesis of arene cis-dihydrodiols has been realized from 2-pyrones through sequential ytterbium-catalyzed asymmetric inverse-electron-demand Diels–Alder (IEDDA) reaction of 2-pyrones and retro-Diels–Alder extrusion of CO2. By using this strategy, a series of substituted arene cis-dihydrodiols can be obtained efficiently with high enantioselectivity (>99 % ee in many cases). Based on this strategy, efficient and concise asymmetric total syntheses of (+)-MK7607 and 1-epi-(+)-MK7607 were accomplished.