26011-57-4

Basic information

• Product Name: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE
• Synonyms: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE;3,4-DIHYDRO-2H-BENZO[1,4]OXAZIN-6-YL-AMINE;3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-AMINE;2H-1,4-Benzoxazin-6-amine,3,4-dihydro-(9CI);3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE SULFATE
• CAS NO: 26011-57-4
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: AMINEPRIMARY
• Mol File: 26011-57-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 335.8 °C at 760 mmHg
• Flash Point: 156.9 °C
• Appearance: /
• Density: 1.195 g/cm³
• Vapor Pressure: 0.000117mmHg at 25°C
• Refractive Index: 1.6
• PKA: 5.87±0.20(Predicted)
• CAS DataBase Reference: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE(26011-57-4)
• EPA Substance Registry System: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-AMINE(26011-57-4)

Safety Data

• Hazardous Substances Data: 26011-57-4(Hazardous Substances Data)

Usage

General Description

3,4-Dihydro-2H-1,4-benzoxazin-6-amine, also known as DIMBOA, is a naturally occurring chemical found in many plants, particularly in the Poaceae family. It is a type of benzoxazinoid, which are compounds produced by plants as a defense mechanism against herbivores and pathogens. DIMBOA has been shown to have allelopathic effects, inhibiting the growth of competing plants by releasing into the soil. It also exhibits antibacterial, antifungal, and antiviral properties, making it useful for plant protection. Additionally, DIMBOA has potential applications in pharmaceuticals, with research indicating its potential as an anticancer and anti-inflammatory agent. Its diverse range of biological activities and natural origin make it a valuable compound in various fields, including agriculture, medicine, and ecological research.

InChI:InChI=1/C8H10N2O/c9-6-1-2-8-7(5-6)10-3-4-11-8/h1-2,5,10H,3-4,9H2

Upstream product

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• 70643-19-5 2,4-diamino-1-(β-hydroxyethyloxy)benzene 

Downstream Products

• 1403816-58-9 N-(5-phenyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-amine 
• 1403817-04-8 N-(5-(2-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-amine 
• 1403816-97-6 N-(5-(3-(pyridin-3-yl)phenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-amine 
• 1403816-83-0 N-(5-(3-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-amine 
• 1403816-81-8 N-(5-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-amine 

Relevant articles and documents

NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS FAK/AURORA KINASE INHIBITORS

This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

2-(Quinolonyl)-fused heterocycles as androgen receptor modulators

The present invention is directed to novel 2-(quinolonyl)-fused heterocyclyl derivatives of the general formula (I) wherein R1, R2, R3, R3a, R4, R5, R6 and R7 are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.