260391-46-6

Basic information

• Product Name: 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester
• Synonyms: 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester
• CAS NO: 260391-46-6
• Molecular Weight: 504.561
• Mol File: 260391-46-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester(260391-46-6)
• EPA Substance Registry System: 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester(260391-46-6)

Safety Data

• Hazardous Substances Data: 260391-46-6(Hazardous Substances Data)

Upstream product

• 260391-71-7 (2-Amino-4,5-dimethoxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone 
• 65935-47-9 2-(phenylthio)ethyl chloroformate 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 74063-48-2 2-Phenylsulfonylethylchloroformate (PSEC) 
• 71461-30-8 (S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester 
• 20611-21-6 2-(phenylsulfonyl)ethanol 
• 699-12-7 2-(phenylthio)ethanol 
• 6216-63-3 N-Cbz-Prolinol 
• 260391-72-8 [2-((S)-2-Dimethoxymethyl-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2-benzenesulfonyl-ethyl ester 
• 260391-48-8 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-phenylsulfanyl-ethyl ester 

Relevant articles and documents

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug

The first example of an N10-protected (e.g., Psec, 15) pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protected PBD prodrugs.