260435-42-5Relevant articles and documents
Tungstale-catalyzed oxidation of triptans with hydrogen peroxide: A novel method for the synthesis of N,N- Dimethyltryptamine N-oxides
Ray, Puma Chandra,Mittapelli, Vasantha,Chauhan, Yogendra Kumar,Konudula, Babu Rao,Tyagi, Om Dutt
experimental part, p. 134 - 136 (2009/12/01)
A straight forward oxidation method of triptans have been described for the synthesis of N,N-dimethyl-Z-[5-[substituted-lH-indole-3-yl]ethanamine-N-oxides using sodium tungstate and 30% aqueous hydrogen peroxide solution in the presence of methanesulphonic acid. The significance of the process is its simplicity and efficiency in isolating the triptan N-oxide derivatives as free base and as malate salt.