26050-99-7

Basic information

• Product Name: Cyclopropanecarboxylic acid, 4-nitrophenyl ester
• CAS NO: 26050-99-7
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.186
• Mol File: 26050-99-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclopropanecarboxylic acid, 4-nitrophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 4-nitrophenyl ester(26050-99-7)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 4-nitrophenyl ester(26050-99-7)

Safety Data

• Hazardous Substances Data: 26050-99-7(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 1759-53-1 cyclopropanecarboxylic acid 
• 4195-18-0 4-nitrophenyl 4-methylpentanoate 
• 1956-09-8 4-nitrophenyl decanoate 
• 104013-15-2 2-phenylpropionic acid p-nitrophenyl ester 
• 14617-86-8 4-nitrophenyl stearate 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 2635-84-9 p-nitrophenyl butyrate 
• 13551-17-2 cyclohexanecarboxylic acid 4-nitrophenyl ester 
• 17895-71-5 p-nitrophenyl hydrocinnamate 
• 959-22-8 p-nitrophenylbenzoate 
• 42721-91-5 4-nitrophenyl cyclopentanecarboxylate 
• 72289-61-3 phenyl-2 butyrate de p-nitrophenyle 
• 830-03-5 4-nitrophenol acetate 
• 321865-45-6 cyclobutanecarboxylic acid 4-nitrophenyl ester 
• 1182415-13-9 methyl 1-[4-(acetylamino)phenyl]cyclopropanecarboxylate 
• 109568-82-3 benzylamine; 4-nitro-phenolate 
• 35665-25-9 cyclopropanecarboxylic acid benzylamide 

Relevant articles and documents

Fingerprint lipolytic enzymes with chromogenic p-nitrophenyl esters of structurally diverse carboxylic acids

A series of structurally diverse chromogenic esters, including a new compound (4-nitrophenyl 2-methylpentanoate), has been synthesized, constituting an array of 17 substrates which could be applied to rapidly fingerprint the activity of lipases or esterases to reveal their substrates specificity and functional characteristics. Combined with genetic technology such as "data mining" and directed evolution, such fingerprints might be a promising platform for discovery of potentially useful enzymes in industrial application. The fingerprint of commercially available Lipase-B from Candida antarctica as a model enzyme was first measured to confirm the reliability of this method. Then three new enzymes mined from genomic libraries were successfully fingerprinted, revealing the functional characteristics of those enzymes. Among them, the enzyme SrfAD was founded with specific substrate preference towards cycloalkyl carboxylic esters and aromatic esters, making it more promising in synthetic utilities than other tested enzymes.

Kinetics and mechanism of the aminolysis of phenyl cyclopropanecarboxylates in acetonitrile

Kinetic studies of the reaction of Z-phenyl cyclopropanecarboxylates with X-benzylamines in acetonitrile at 55.0 °C have been carried out. The reaction proceeds by a stepwise mechanism in which the rate-determining step is the breakdown of the zwitterionic tetrahedral intermediate, T±, with a hydrogen-bonded four-center type transition state (TS). These mechanistic conclusions are drawn based on (i) the large magnitude of ρX and ρZ, (ii) the normal kinetic isotope effects (KH/kD > 1.0) involving deuterated benzylamine nucleophiles, (iii) the positive sign of ρXZ and the larger magnitude of ρXZ than that for normal SN2 processes, and lastly (iv) adherence to the reactivity-selectivity principle (RSP) in all cases.