2611-88-3

Basic information

• Product Name: N-ME-PHG-OH
• Synonyms: N-METHYL-L-PHENYLGLYCINE;N-ME-PHENYLGLYCINE;N-ME-PHG-OH;N-ALPHA-METHYL-L-PHENYLGLYCINE;H-MEPHG-OH;H-N-ME-PHG-OH;H-L-MePhg-OH;Benzeneacetic acid, a-(MethylaMino)-, (aS)-
• CAS NO: 2611-88-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Product Categories: amino acid
• Mol File: 2611-88-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 245-246 °C
• Boiling Point: 275.0±28.0 °C(Predicted)
• Appearance: /
• Density: 1.155±0.06 g/cm3(Predicted)
• Storage Temp.: Store at RT.
• PKA: 1.86±0.10(Predicted)
• CAS DataBase Reference: N-ME-PHG-OH(CAS DataBase Reference)
• NIST Chemistry Reference: N-ME-PHG-OH(2611-88-3)
• EPA Substance Registry System: N-ME-PHG-OH(2611-88-3)

Safety Data

• Hazardous Substances Data: 2611-88-3(Hazardous Substances Data)

Usage

General Description

N-ME-PHG-OH is a chemical compound with the molecular formula C9H9NO3. It is also known as N-methyl phenylglycine hydroxamic acid and is a derivative of phenylhydroxamic acid. N-ME-PHG-OH has been studied for its potential anti-inflammatory and anti-tumor properties. It has been found to inhibit the activity of histone deacetylase (HDAC), which plays a role in regulating gene expression and has been implicated in cancer progression. N-ME-PHG-OH may also have potential applications in the development of new pharmaceuticals for treating various diseases.

Upstream product

• 74641-60-4 2-methylamino-2-phenylacetic acid 
• 93529-76-1 (S)-(Dimethylamino-methyleneamino)-phenyl-acetic acid methyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 74-89-5 methylamine 
• 220808-97-9 (2S)-(methyl{[(phenylmethyl)oxy]carbonyl}amino)(phenyl)ethanoic acid 
• 593-51-1 methylamine hydrochloride 
• 611-73-4 Benzoylformic acid 
• 61857-93-0 α-methylamino phenylacetamide 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 
• 221270-65-1 phenylmethyl (4S)-5-oxo-4-phenyl-1,3-oxazolidine-3-carboxylate 
• 4870-65-9 2-bromophenylacetic acid 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 74-88-4 methyl iodide 
• 43195-94-4 (R)-2-chloro-2-phenylacetic acid 

Downstream Products

• 143394-39-2 (S)-(+)-2-(N-methylamino)-2-phenylethanol 

Relevant articles and documents

Enzymatic synthesis of N-methyl-L-phenylalanine by a novel enzyme, N-methyl-L-amino acid dehydrogenase, from Pseudomonas putida

An enzymatic system for the synthesis of N-methyl-l-phenylalanine from phenylpyruvic acid and methylamine with a novel enzyme, N-methyl-l-amino acid dehydrogenase from Pseudomonas putida ATCC12633, using NADP+ and glucose dehydrogenase from Bacillus subtilis as a co-factor-recycling system is described. Analysis of the product on a laboratory preparative scale process revealed N-methyl-l-phenylalanine in 98% yield and over 99% ee. N-Methyl-l-phenylalanine can be used as chiral building blocks for the synthesis of several products with pharmacological activity.

Preparation method of N-methylamino acid with optical configurations

The invention belongs to the field of medicine synthesis, relates to a preparation method of N-methylamino acid with optical configurations and in particular relates to a preparation method of N-methylamino acid with an R configuration and an S configuration. The preparation method is shown in the description. According to the preparation method provided by the invention, the configurations of reactants are transformed to obtain the N-methylamino acid with corresponding opposite configurations, and the preparation method is suitable for commercial scale production.

The facile production of N-methyl amino acids via oxazolidinones

A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids. CSIRO 2000.