2615-11-4

Basic information

• Product Name: 4-ACETYLPHENYL ETHER
• Synonyms: 1,1’-(oxydi-4,1-phenylene)bis-ethanon;1,1’-(oxydi-4,1-phenylene)bisethanone;4,4’-diacetyldiphenyloxide;4,4’-oxybis(acetetophenone);4,4’-oxydiacetophenone;4’,4’’’-oxydi-acetophenon;4’,4’’’-oxydiacetophenone;bis(4-acetylphenyl)ether
• CAS NO: 2615-11-4
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.28
• Product Categories: Aromatic Ethers
• Mol File: 2615-11-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 103-105°C
• Boiling Point: 200°C 1mm
• Flash Point: 182.4 °C
• Appearance: /
• Density: 1.139 g/cm³
• CAS DataBase Reference: 4-ACETYLPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYLPHENYL ETHER(2615-11-4)
• EPA Substance Registry System: 4-ACETYLPHENYL ETHER(2615-11-4)

Safety Data

• Hazardous Substances Data: 2615-11-4(Hazardous Substances Data)

Usage

General Description

4-acetylphenyl ether, also known as PEA or p-acetylphenyl ether, is an organic chemical compound with the empirical formula C10H10O2 and the IUPAC name of 1-(4-ethoxyphenyl)ethan-1-one. As the name suggests, it contains a phenyl ring (a circular arrangement of carbon atoms) with an ether and an acetyl group attached. 4-ACETYLPHENYL ETHER is notable for its presence in various types of essential oils. It serves several functions in several industries, predominantly used in the manufacturing of perfumes due to its pleasant aroma, and also used as an intermediate in the synthesis of various pharmaceutical and chemical products.

Upstream product

• 101-84-8 diphenylether 
• 75-36-5 acetyl chloride 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 13329-40-3 4-Iodoacetophenone 
• 23713-93-1 4,4'-oxybis(ethylbenzene) 
• 99-90-1 para-bromoacetophenone 
• 99-93-4 4-Hydroxyacetophenone 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 99-96-7 4-hydroxy-benzoic acid 
• 108-24-7 acetic anhydride 
• 149104-90-5 4-acetylphenylboronic acid 
• 86538-21-8 bis<4-(1-ethoxyethyl)phenyl> ether 

Downstream Products

• 2215-89-6 oxybis(benzoic acid) 
• 21368-80-9 1,1'-oxybis(4-ethynylbenzene) 
• 93868-13-4 4,4'-Bis-dichloracetyl-diphenylether 
• 28160-62-5 4,4'-Bis-dibromacetyl-diphenylether 
• 912675-35-5 1-[4-(4-acetylphenoxy)phenyl]-4-(2-chlorophenyl)butane-1,4-dione 
• 1047677-37-1 3-{4-[4-(2-ethoxycarbonyl-1-methylvinyl)phenoxy]phenyl}but-2-enoic acid ethyl ester 
• 17027-93-9 C₁₈H₂₂N₈O 
• 4073-80-7 bis(p-bromoacetylphenyl) ether 
• 2489-92-1 4,4'-bis(phenylglyoxalyl) ether 
• 88121-76-0 1-{4-[4-(3-Quinolin-2-yl-benzo[f]quinolin-1-yl)-phenoxy]-phenyl}-ethanone 

Relevant articles and documents

The role of ancillary ligand on regulating photoluminescence properties of Eu(III) helicates

Three binuclear Eu3+ helicates, [Eu2(OBTA)3(H2O)3(CH3COCH3)]·1.5CH3COCH3·H2O (1), [Eu2(OBTA)3(Bpy)2]·2CH3/

Nickel-Catalyzed Etherification of Phenols and Aryl Halides through Visible-Light-Induced Energy Transfer

Notwithstanding some progress in nickel-catalyzed etherification of alkanols and arylhalides, the ability of such a Ni-catalyzed transformation employing phenols to diaryl ethers is unsuccessful due to phenolates with much lower reduction potentials, which suppress the oxidation of nickel(II) intermediates into requisite Ni(III) species. We herein report visible-light-initiated, nickel-catalyzed O-arylation of phenols with arylhalides using t-BuNH(i-Pr) as the base and thioxanthen-9-one as the photosensitizer under visible light. This photocoupling exhibits a broad substrate scope.

Diaryl Ether Formation Merging Photoredox and Nickel Catalysis

Photoredox and Ni catalysis are combined to produce diaryl ethers under mild conditions. A broad range of aryl halides and phenol derivatives are cross-coupled in the presence of a readily available organic photocatalyst and NiBr2(dtbpy). Symmetrical diaryl ethers have also been directly obtained from aryl bromides in the presence of water. Mechanistic investigations support the involvement of Ni(0) species at the outset of the reaction and a Ni(II)/Ni(III)-photocatalyzed single electron transfer process preceding the productive C(sp2)-OAr reductive elimination.