26159-36-4

Basic information

• Product Name: Naproxol
• Synonyms: Naproxol;(S)-2-(6-Methoxy-2-naphtyl)-1-propanol;[S,(-)]-6-Methoxy-β-methyl-2-naphthaleneethanol;RS-4034;(S)-2-(6-methoxy-naphthalen-2-yl)propan-1-ol;6-Methoxy-2-(2-methylhydroxyethyl)naphthalene
• CAS NO: 26159-36-4
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.278
• Mol File: 26159-36-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 362.9°Cat760mmHg
• Flash Point: 162.6°C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 6.67E-06mmHg at 25°C
• Refractive Index: 1.597
• PKA: 14.75±0.10(Predicted)
• CAS DataBase Reference: Naproxol(CAS DataBase Reference)
• NIST Chemistry Reference: Naproxol(26159-36-4)
• EPA Substance Registry System: Naproxol(26159-36-4)

Safety Data

• Hazardous Substances Data: 26159-36-4(Hazardous Substances Data)

Usage

Description

Naproxol, also known as Naproxen, is an aromatic ether with the chemical structure featuring 6-[(2S)-1-hydroxypropan-2-yl]-2-naphthyl and methyl substituents on oxygen. It is a nonsteroidal anti-inflammatory drug (NSAID) that is widely used for its analgesic, anti-inflammatory, and antipyretic properties.

Uses

Used in Pharmaceutical Industry:
Naproxol is used as an anti-inflammatory agent for reducing inflammation and pain associated with various conditions such as arthritis, tendonitis, and other musculoskeletal disorders. Its ability to inhibit cyclooxygenase (COX) enzymes helps in decreasing the production of prostaglandins, which are responsible for inflammation and pain.
Naproxol is used as an analgesic for alleviating mild to moderate pain, such as headaches, menstrual cramps, and dental pain. Its pain-relieving properties make it a popular choice for managing various types of discomfort.
Naproxol is used as an antipyretic to reduce fever and lower body temperature in cases of mild to moderate fever caused by infections or other inflammatory conditions.

InChI:InChI=1/C14H16O2/c1-10(9-15)11-3-4-13-8-14(16-2)6-5-12(13)7-11/h3-8,10,15H,9H2,1-2H3/t10-/m1/s1

Upstream product

• 27602-75-1 2-(6-methoxy-2-naphthyl)propanal 
• 960210-90-6 1-phenylethyl 2-(6-methoxynaphthalen-2-yl)propionate 
• 159990-32-6 (S)-2-(6-methoxy-2-naphthyl)-1,2-propanediol 

Downstream Products

• 1198163-33-5 C₄₀H₃₈BrO₃P 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 23979-41-1 (R)-2-(6-methoxy-2-naphthyl)propionic acid 

Relevant articles and documents

Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenases

We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2S)-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and high enantioselectivity towards the (S)-enantiomer obtained in the bioreduction of 2-arylpropionic aldehydes, clearly indicate the achievement of a DKR process through a combination of an enzyme-catalyzed kinetic reduction with a chemical base-catalyzed racemization of the unreacted aldehydes. The racemization step is represented by the keto-enol equilibrium of the aldehyde and can be controlled by modulating pH and reaction conditions.

Probing the parallel kinetic resolution of 1-phenylethanol using quasi-enantiomeric oxazolidinone adducts

The parallel kinetic resolution of racemic 1-phenylethanol using an equimolar combination of quasi-enantiomeric oxazolidinones is discussed. The levels of diastereoselectivity were high leading to separable quasi-enantiomeric esters in good yield.

A modification of the asymmetric dihydroxylation approach to the synthesis of (S)-2-arylpropanoic acids

Catalytic hydrogenolysis of (S)-2-phenyl-1-2-propanediol (2), prepared by an asymmetric dihydroxylation of α-methylstyrene (1) with AD-mix-α, over Pearlman's catalyst gave (S)-2-phenyl-1-propanol (3). This method was applied to the synthesis of optically active 2-arylpropanoic acid antiinflammatory agents, (S)-ibuprofen (8) and (S)-naproxen (13).