261704-60-3

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-(2-chlorophenyl)-5-phenyl-
• CAS NO: 261704-60-3
• Molecular Formula: C14H9ClN2O
• Molecular Weight: 256.691
• Mol File: 261704-60-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-(2-chlorophenyl)-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-(2-chlorophenyl)-5-phenyl-(261704-60-3)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-(2-chlorophenyl)-5-phenyl-(261704-60-3)

Safety Data

• Hazardous Substances Data: 261704-60-3(Hazardous Substances Data)

Upstream product

• 86339-13-1 N-benzoyloxy-2-chloro-benzamidine 
• 73289-49-3 N-acetyl methyl benzimidate 
• 56935-60-5 2-chlorobenzamidooxime 
• 3717-26-8 2-chlorobenzaldoxime 
• 56935-60-5 2-chloro-benzamide oxime 
• 29568-74-9 2-chloro-N-hydroxybenzimidoyl chloride 
• 873-32-5 2-Chlorobenzonitrile 
• 2579-22-8 Phenylpropargyl aldehyde 
• 18637-02-0 2-chlorobenzene-1-carboximidamide hydrogenchloride 
• 108-88-3 toluene 
• 93-58-3 benzoic acid methyl ester 
• 89-98-5 2-chloro-benzaldehyde 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

Oxidative cyclization of amidoximes and thiohydroximic acids: A facile and efficient strategy for accessing 3,5-disubstituted 1,2,4-oxadiazoles and 1,4,2-oxathiazoles

A facile and practical protocol has been developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles and 1,4,2-oxathiazoles through oxidative cyclization of amidoximes and thiohydroximic acids, respectively at room temperature. Use of mild reaction

A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

Various 3,5-disubstituted-1,2,4-oxadiazoles are smoothly formed via copper-catalyzed cascade annulation of amidines and methylarenes. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 1,2,4-oxadiazoles from easily available starting materials, with inexpensive copper catalysts and green oxidants. It has the advantages of atom- and step-economy, good functional group tolerance, as well as operational simplicity.