26186-01-6Relevant articles and documents
IMIDAZOQUINOLINE AMINE DERIVATIVES, PHARMACEUTICAL COMPOSITION, USE THEREOF
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Paragraph 00183, (2020/08/22)
The invention provides novel imidazoquinoline amine derivatives, having agonistic activities to Toll-like receptors (TLRs), in particular TLR7 and/or TLR8, pharmaceutical compositions thereof, and methods of treatment, reduction or prevention of certain d
Synthesis of α-O- and α-S-glycosphingolipids related to sphingomonous cell wall antigens using anomerisation
Pilgrim, Wayne,O'Reilly, Ciaran,Murphy, Paul V.
, p. 11198 - 11218 (2013/10/22)
Analogues of glycolipids from Spingomonadacaece with O- and S- and SO 2-linkages have been prepared using chelation induced anomerisation promoted by TiCl4. Included are examples of the anomerisation of intermediates with O- and S-glycosidic linkages as well as isomerisation of β-thioglycuronic acids (β-glycosyl thiols). The β-O-glucuronide and β-O-galacturonide precursors were efficiently prepared using benzoylated trichloroacetimidates. β-Glycosyl thiols were precursors to β-S-derivatives. Triazole containing mimics of the natural glycolipids were prepared using CuI promoted azide-alkyne cycloaddition reactions in THF. The glycolipid antigens are being evaluated currently for their effects on iNKT cells.
A convenient scalable one-pot conversion of esters and Weinreb amides to terminal alkynes
Dickson, Hamilton D.,Smith, Stephon C.,Hinkle, Kevin W.
, p. 5597 - 5599 (2007/10/03)
Esters and amides undergo reduction to the corresponding aldehydes using DIBAL-H followed by same pot conversion to terminal alkynes utilizing the Bestmann-Ohira reagent in good to excellent yields. Additionally chiral nonracemic substrates undergo this transformation with complete preservation of stereochemical integrity.
