2620-89-5

Basic information

• Product Name: Benzamide,2,2'-dithiobis[N-cyclohexyl- (7CI,9CI)
• Synonyms: 2,2'-Dithiobis(N-cyclohexylbenzamide)
• CAS NO: 2620-89-5
• Molecular Formula: C₂₆H₃₂N₂O₂S₂
• Molecular Weight: 468.684
• Mol File: 2620-89-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 662.1 °C at 760 mmHg
• Flash Point: 354.2 °C
• Density: 1.24 g/cm³
• CAS DataBase Reference: Benzamide,2,2'-dithiobis[N-cyclohexyl- (7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide,2,2'-dithiobis[N-cyclohexyl- (7CI,9CI)(2620-89-5)
• EPA Substance Registry System: Benzamide,2,2'-dithiobis[N-cyclohexyl- (7CI,9CI)(2620-89-5)

Safety Data

• Hazardous Substances Data: 2620-89-5(Hazardous Substances Data)

Upstream product

• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 108-91-8 cyclohexylamine 
• 119-80-2 2,2'-dithiobenzoic acid 
• 147-93-3 Thiosalicylic acid 
• 77586-83-5 2-trichloromethyl-3,1-benzoxathian-4-one 

Downstream Products

• 2527-02-8 2-cyclohexyl-1,2-benzisothiazol-3(2H)-one 

Relevant articles and documents

Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors

Carbapenem-resistant Enterobacteriaceae (CRE) producing New Delhi metallo-β-lactamase (NDM-1) cause untreatable bacterial infections, posing a significant threat to human health. In the present study, by employing the concept of bioisosteric replacement of the selenium moiety of ebselen, we have designed, synthesized and characterized a small compound library of 2-substituted 1,2-benzisothiazol-3(2H)-one derivatives and related compounds for evaluating their cytotoxicity and synergistic activity in combination with meropenem against the E. coli Tg1 (NDM-1) strain. The most promising compound 3a demonstrated potent synergistic activity against a panel of clinically isolated NDM-1 positive CRE strains with FICI as low as 0.09. Moreover, its IC50 value and inhibition mechanism were also confirmed by using the enzyme inhibition assay and the ESI-MS analysis respectively. Importantly, compound 3a has acceptable toxicity and is not a PAINS. Because of its structural simplicity and potent synergistic activity in combination with meropenem, we propose that compound 3a may be a promising meropenem adjuvant and a new series of such compounds may worth further investigations.

Antithrombotic agent

Certain 2,2'-dithiobis-N-substituted or unsubstituted benzamides or derivatives thereof are useful as antithrombotic agents because of their ability to suppress aggregation of blood platelets.