26215-14-5

Basic information

• Product Name: 7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: TIMTEC-BB SBB010445;7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE;7-AMINO-4H-BENZO[1,4]OXAZIN-3-ONE;7-amino-2H-benzo[b][1,4]oxazin-3(4H)-one;7-amino-2H-1,4-benzoxazin-3(4H)-one(SALTDATA: FREE);7-Amino-3,4-dihydro-3-oxo-2H-1,4-benzoxazine;7-aMino-3,4-dihydro-2H-1,4-benzoxazin-3-one
• CAS NO: 26215-14-5
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16
• Mol File: 26215-14-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 215-218°C
• Boiling Point: 434.8 °C at 760 mmHg
• Flash Point: 216.7 °C
• Appearance: /
• Density: 1.344 g/cm³
• Vapor Pressure: 9.23E-08mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.43±0.20(Predicted)
• CAS DataBase Reference: 7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE(26215-14-5)
• EPA Substance Registry System: 7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE(26215-14-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-52
• HazardClass: IRRITANT
• Hazardous Substances Data: 26215-14-5(Hazardous Substances Data)

Usage

Description

7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE is a chemical compound belonging to the benzoxazinone class, characterized by its unique structure and properties. It is known for its potential applications in various fields, particularly in the pharmaceutical industry.
Used in Pharmaceutical Industry:
7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE is used as a reagent for the preparation of benzo-oxazinones, which are compounds with anticonvulsant properties. These benzo-oxazinones can be utilized in the development of medications to treat epilepsy and other seizure disorders, providing an alternative treatment option for patients.
7-AMINO-2H-1,4-BENZOXAZIN-3(4H)-ONE is also used as a precursor in the synthesis of other bioactive compounds, which can be further explored for their potential therapeutic applications in various medical conditions. Its unique structure and properties make it a valuable component in the development of new drugs and pharmaceutical agents.

InChI:InChI=1/C8H8N2O2/c9-5-1-2-6-7(3-5)12-4-8(11)10-6/h1-3H,4,9H2,(H,10,11)

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 95-55-6 2-amino-phenol 
• 121-88-0 5-Nitro-2-aminophenol 
• 81721-86-0 7-nitro-4H-benzo[1,4]oxazin-3-one 

Downstream Products

• 120711-66-2 6-(2-imidazolin-2-ylamino)-2H-1,4-benzoxazin-3(4H)-one hydroiodide 
• 130137-41-6 N-phenyl-N'-(3-oxo-2H-1,4-benzoxazin-7-yl)thiourea 
• 130137-42-7 1-(4-Chloro-phenyl)-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-thiourea 
• 130137-43-8 1-(4-Bromo-phenyl)-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-thiourea 
• 105202-20-8 7-amino-4H-benz[1,4]oxazin-3-one; hydrochloride 
• 1042317-68-9 C₁₆H₁₆N₂O₂ 
• 1042317-51-0 C₁₅H₁₃FN₂O₂ 
• 1042317-58-7 C₁₅H₁₃ClN₂O₂ 
• 1042317-62-3 C₁₅H₁₃ClN₂O₂ 
• 1042317-75-8 C₁₇H₁₈N₂O₃ 
• 1042317-49-6 C₁₅H₁₄N₂O₂ 
• 1042317-71-4 C₁₅H₁₄N₂O₃ 
• 1042317-73-6 C₁₆H₁₆N₂O₃ 
• 90814-95-2 C₁₅H₁₂N₂O₃ 

Relevant articles and documents

Anticonvulsant and toxicity evaluation of newer 4H-benzo[1,4]oxazin-3-ones: The effect of two hydrogen bonding domains

A series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides (6a-r) was synthesized using 2-amino-5-nitrophenol as a starting material. All the synthesized compounds possessed two hydrogen-bonding domains and their effect on the activity was studied thereof. The anticonvulsant activity was assessed by the maximal electroshock test (MES), subcutaneous pentylenetetrazole test (scPTZ) and intraperitoneal thiosemicarbazide test (ipTSC). Compounds (6b, 6h, 6i, and 6p) were found to be the most potent of the series as they showed 83-100% protection in the MES test. They also displayed considerable activity in the chemically induced seizure tests. Most of the tested compounds were devoid of the neurotoxic and hepatotoxic effects. A series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin- 7-yl) hydrazine carboxamides (6a-r) was synthesized. Four compounds were found to be very promising as far as efficacy and safety is concerned. They may act as lead molecules for future investigations. Copyright

ALKYL-SUBSTITUTED 3' COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, Ar, m and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

ACYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, Q, G, Ar, m, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.