2622-74-4Relevant articles and documents
Synthesis and characterization of 2-substituted benzimidazoles and their evaluation as anticancer agent
Azam, Mohammad,Khan, Azmat Ali,Al-Resayes, Saud I.,Islam, Mohammad Shahidul,Saxena, Ajit Kumar,Dwivedi, Sourabh,Musarrat, Javed,Trzesowska-Kruszynska, Agata,Kruszynski, Rafal
, p. 286 - 291 (2015)
In this work, we report a series of benzimidazole derivatives synthesized from benzene-1,2-diamine and aryl-aldehydes at room temperature. The synthesized compounds have been characterized on the basis of elemental analysis and various spectroscopic studi
Synthesis and characterization of green-emitting phosphorescent Ir(III) complexes based on phenyl benzimidazole ligand
Lin, Meijuan,Tang, Qiang,Zeng, Huijuan,Xing, Guang,Ling, Qidan
, p. 1747 - 1752 (2016)
Several new Ir(III) complexes with 2-(4-bromophenyl)-1H-benzo[d]imidazole or 2-(4-bromophenyl)- 1-methyl-benzo[d]imidazole ligands as cylcometalated ligand and acetylacetonate or picolinate as the ancillary ligand were synthesized and their structures and
An Unexpected Formation of 2-Arylbenzimidazoles from α,α-Diiodo-α’-acetoxyketones and o-Phenylenediamines
Sadhukhan, Santu,Mondal, Swagata,Baire, Beeraiah
, (2022/03/01)
An unusual reactivity of the α,α-diiodo-α’-acetoxyketones with o-phenylenediamines is reported through the formation of 2-arylbenzimidazoles. A systematic study through a series of fruitful control experiments and isolation of key intermediates unravelled the unprecedented domino mechanism. This process involves a stepwise two-carbon fragmentation pathway through domino and sequential amidation–aziridination–decarbonylation–I2-mediated aminative cyclization–oxidation reactions. This strategy employs no additives like oxidant, metal catalyst, bases, and represents yet another novel reactivity profile of the building blocks α,α-diiodo-α’-acetoxyketones.
Method for catalytically synthesizing phenylbenzimidazole compound by using copper complex
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Paragraph 0043-0046, (2021/08/06)
The invention relates to a method for catalytically synthesizing a phenylbenzimidazole compound by using a copper complex, which comprises the following steps: in the presence of alkali, taking benzimidazole and halogenated hydrocarbon as raw materials, taking the copper complex containing meta-carborane ligand as a catalyst, and conducting reacting at room temperature to prepare the phenylbenzimidazole compound. Compared with the prior art, the method has the advantages that the halogenated hydrocarbon compound which is low in cost and easy to obtain is used as the substrate, the reaction of benzimidazole and halogenated hydrocarbon is efficiently catalyzed by using the copper complex, the phenylbenzimidazole compound is synthesized by a one-pot method, the reaction condition is mild, the universality is good, the catalytic efficiency is high, few byproducts are produced, the cost is relatively low, the product is easy to separate, and lots of waste residues cannot be generated.
Preparation method of 2-substituted benzimidazole compound
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Paragraph 0084-0088, (2021/02/20)
The invention discloses a preparation method of a 2-substituted benzimidazole compound, and belongs to the field of synthesis of benzimidazole compounds. The 2-substituted benzimidazole compound is synthesized in an organic solvent by taking an o-nitroaniline compound, aromatic aldehyde, o-dinitrobenzene and aromatic aldehyde as raw materials and taking Co particles wrapped by a nitrogen-doped carbon material as a catalyst. According to the method, the 2-substituted benzimidazole compound can be prepared at room temperature, the reaction conditions are mild, the yield is as high as 95%, the selectivity is as high as 99%, and the method is economical, environmentally friendly and wide in substrate applicability. The used catalyst is easy to prepare, low in cost and good in reusability, canbe separated by utilizing magnetism, and is convenient to recover, so that the method has a relatively strong industrial application prospect.