262375-60-0Relevant articles and documents
Enantioselective total synthesis of epothilone A using multifunctional asymmetric catalyses
Sawada, Daisuke,Shibasaki, Masakatsu
, p. 209 - 213 (2007/10/03)
A catalytic version has now been developed for the enantioselective total synthesis of epothilone A (1). The key is the use of multifunctional asymmetric catalySes for a direct aldol reaction and cyanosilylation. This successful approach demonstrated the usefulness of these reactions for the catalytic asymmetric synthesis of complex molecules.