262419-96-5

Basic information

• Product Name: (4R)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid N-methoxy-N-methylamide
• Synonyms: (4R)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid N-methoxy-N-methylamide
• CAS NO: 262419-96-5
• Molecular Weight: 266.321
• Mol File: 262419-96-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (4R)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid N-methoxy-N-methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid N-methoxy-N-methylamide(262419-96-5)
• EPA Substance Registry System: (4R)-2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid N-methoxy-N-methylamide(262419-96-5)

Safety Data

• Hazardous Substances Data: 262419-96-5(Hazardous Substances Data)

Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 115921-06-7 (R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid 
• 611-20-1 salicylonitrile 

Downstream Products

• 885279-11-8 2-(2-methoxyphenyl)thiazole-4-carbaldehyde 
• 828936-79-4 2'-(2-hydroxyphenyl)-2'-thiazole-4'-(N-methoxy-N-methyl)carboxamide 
• 338985-68-5 pyochelin 
• 69772-54-9 (4'R,2''R,4''R)-2'-(2-hydroxyphenyl)-3''-methyl-2'',3'',4'',4',5'-hexahydro-[2,4']-bisthiazolyl-4''-carboxylic acid 
• 69772-54-9 (4'S,2''R,4''R)-2'-(2-hydroxyphenyl)-3''-methyl-2'',3'',4'',4',5'-hexahydro-[2,4']-bisthiazolyl-4''-carboxylic acid 
• 163526-41-8 2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxaldehyde 

Relevant articles and documents

Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa

Pyochelin is a siderophore common to all strains of Pseudomonas aeruginosa utilized by this Gram-negative bacterium to acquire iron(III). FptA is the outer membrane transporter responsible of ferric-pyochelin uptake in P. aeruginosa. We describe in this Letter the synthesis and the biological properties ( 55Fe uptake, binding to FptA) of several thiazole analogues of pyochelin. Among them we report in this Letter the two first pyochelin analogues able to bind FptA without promoting any iron uptake in P. aeruginosa.

Synthetic studies of thiazoline and thiazolidine-containing natural products. Part 3: Total synthesis and absolute configuration of the siderophore yersiniabactin

Total synthesis of yersiniabactin, a siderophore from cultures of the bacterium Yersinia enterocolitica, was accomplished. Chirality at the readily racemizable C-9 carbon was preserved during cyclization of β-hydroxythioamide by means of Burgess reagent leading to thiazoline. Based on its synthesis, the absolute configuration of natural yersiniabactin has been determined as 9R, 10RS, 12R, 13S and 19S.