262444-15-5

Basic information

• Product Name: (4-BROMOTHIAZOL-5-YL)METHANOL
• Synonyms: (4-broMo-1,3-thiazol-5-yl)Methanol;(4-Bromothiazol-5-yl);(4-BROMOTHIAZOL-5-YL)METHANOL
• CAS NO: 262444-15-5
• Molecular Formula: C₄H₄BrNOS
• Molecular Weight: 194.06
• Mol File: 262444-15-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 314.378°C at 760 mmHg
• Flash Point: 143.931°C
• Appearance: /
• Density: 1.9g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.89±0.10(Predicted)
• CAS DataBase Reference: (4-BROMOTHIAZOL-5-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMOTHIAZOL-5-YL)METHANOL(262444-15-5)
• EPA Substance Registry System: (4-BROMOTHIAZOL-5-YL)METHANOL(262444-15-5)

Safety Data

• Hazardous Substances Data: 262444-15-5(Hazardous Substances Data)

Usage

Description

(4-Bromothiazol-5-yl)methanol is an organic compound that features a thiazol ring with a bromine atom at the 4-position and a hydroxyl group attached to a methyl group. This unique structure makes it a valuable intermediate in the synthesis of various heterocyclic compounds.

Uses

Used in Pharmaceutical Industry:
(4-Bromothiazol-5-yl)methanol is used as a research reactant for the synthesis of substituted pyrazoles and imidazoles, which are important classes of heterocyclic compounds with a wide range of biological activities. These compounds have potential applications as pharmaceutical agents, including anticancer, antiviral, and antimicrobial properties.
Used in Chemical Research:
In the field of chemical research, (4-Bromothiazol-5-yl)methanol serves as a versatile building block for the development of new organic compounds with potential applications in various industries, such as materials science, agrochemicals, and dyes. Its reactivity and functional groups make it suitable for further chemical modifications and the creation of novel molecules with desired properties.

InChI:InChI=1/C4H4BrNOS/c5-4-3(1-7)8-2-6-4/h2,7H,1H2

Upstream product

• 170232-68-5 (2,4-dibromo-1,3-thiazol-5-yl)methanol 

Downstream Products

• 38585-74-9 thiazol-5-yl-methanol 
• 1244948-92-2 4-bromothiazole-5-carboxaldehyde 

Relevant articles and documents

Rapid and efficient synthesis of stable isotope labeled [ 13C4, D4]-5-(hydroxymethyl)thiazole: Versatile building block for biologically interesting compounds

5-(Hydroxymethyl)thiazole is a versatile building block for many biologically active compounds. A rapid and efficient four- step synthesis of its stable isotope labeled counterpart with four 13C and four deuterium atoms in 32% total yield is reported. Condensation of [13C 2]-chloro acetic acid with [13C]-thiourea gave [ 13C3]-2,4-thiazolidinedione. Reaction of [ 13C3]-2,4-thiazolidinedione with phosphorus oxybromide and [13C, D]-DMF (Me2N13CDO) produced [ 13C4 D]-2,4-dibromo- thiazole-5-carboxaldehyde. The resultant aldehyde was then reduced by sodium borodeuteride to [ 13C4, D2]-(2,4-dibromo- thiazol-5-yl)-methanol. Catalytic deuteration of [13C4, D2]-(2,4- dibromo-thiazol-5-yl)-methanol by palladium black with deuterium gas at 1 atm pressure and room temperature produced completely de-brominated [ 13C4, D4]-5-(hydro- xymethyl)thiazole. De-bromination of the 2,4-dibromothiazole by the catalysis of palladium black provides a simple and convenient synthetic method for the stable isotope labeled and potentially radioactive isotope labeled thiazole compounds. Copyright

Pyrrolopyrimidines as therapeutic agents

Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatiod arthritis, disorders of the immune system, trasplant refections and imflammatory disorders.