262598-45-8

Basic information

• Product Name: 2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
• Synonyms: 2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
• CAS NO: 262598-45-8
• Molecular Weight: 1158.69
• Mol File: 262598-45-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel(262598-45-8)
• EPA Substance Registry System: 2',10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel(262598-45-8)

Safety Data

• Hazardous Substances Data: 262598-45-8(Hazardous Substances Data)

Upstream product

• 114915-20-7 Docetaxel 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 
• 52999-57-2 2,2,2-trichloroethylcarbonyl chloride 

Relevant articles and documents

Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid

The synthesis of docetaxel esters of malic acid is described. These compounds were found to have greatly improved water solubility and are stable in solution at neutral pH. The C2′ modified compounds 2a-c and 3a-c behave as prodrugs, that is, docetaxel is

MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES

Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a LN transmembrane pH or ion gradient into the aqueous interior of the LN. The weak-base moiety can optionally comprise a lipophilic domain that facilitates active loading of the drag to the inner monolayer of the liposomal membrane. Advantageously, LN formulations of the drag derivatives exhibit improved solubility, reduced toxicity, enhanced efficacy, and/or other benefits relative to the corresponding free drags.