2627-94-3

Basic information

• Product Name: 17β-(Acetyloxy)-6β-fluoroandrost-4-en-3-one
• Synonyms: 17β-(Acetyloxy)-6β-fluoroandrost-4-en-3-one
• CAS NO: 2627-94-3
• Molecular Formula: C₂₁H₂₉FO₃
• Molecular Weight: 348.4515632
• Mol File: 2627-94-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 17β-(Acetyloxy)-6β-fluoroandrost-4-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-(Acetyloxy)-6β-fluoroandrost-4-en-3-one(2627-94-3)
• EPA Substance Registry System: 17β-(Acetyloxy)-6β-fluoroandrost-4-en-3-one(2627-94-3)

Safety Data

• Hazardous Substances Data: 2627-94-3(Hazardous Substances Data)

Upstream product

• 1778-93-4 3,17-Diacetoxy-Δ^3.5-androstadien 
• 1778-93-4 testosterone enol diacetate 
• 58-22-0 testosterone 
• 25495-29-8 Acetic acid (10R,13S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester 

Downstream Products

• 3591-23-9 6-dehydrotestosterone 
• 1852-58-0 6β-fluoro-17β-hydroxy-4-androsten-3-one 

Relevant articles and documents

Synthesis, Properties, and Reactivity of N,N'-Difluorobipyridinium and Related Salts and Their Applications as Reactive and Easy-To-Handle Electrophilic Fluorinating Agents with High Effective Fluorine Content

N,N′-Difluoro-2,2′-, -2,4′-, -3,3′-, -4,4′-bipyridinium and substituted N,N′-difluoro-2,2′-bipyridinmm bis(triflates), bis(tetrafluoroborates), bis(hexafluorophosphates), and bis(hexafluoroantimonates) 1-9 were synthesized in high yields by the direct fluorination of a mixture of a bipyridyl and a Lewis acid, a Br?nsted acid, or the alkali metal salt of an acid. The higher homologues, trimer 10 and polymer 11, were also synthesized. Unsubstituted or electron-donating group-substituted N,N′- difluorobipyridinium salts are stable nonhygroscopic crystals, while the electron-withdrawing group- substituted N,N′-diflurobipyridinium salts 3, 5, and 6 are moisture-sensitive crystals. Hydrolysis of 1b in boiling water gave 3,3′-dihydroxy-2,2′-bipyridyl. The reactivity determination indicated that the fluorinating capability decreased in the order 2,2′- ? 2,4' > 3,3′- ≈ 4,4′-isomer ? N-fluoropyridinium salt and that the two N-F moieties in a molecule were effective for fluorination. This fluorination occurred in a step-by-step manner, and the reactivity difference between the first and second fluorinations was very small. N,N′-Difluoro-2,2′-bipyridinium bis(tetrafluoroborate) (1b) is thus shown to be a highly reactive and easy-to-handle electrophilic fluorinating agent with the high effective fluorine content (103.3 g/kg) for preparing many fluoro organic compounds.

1-Alkyl-4-fluoro-1,4-diazoniabicyclooctane Salts: a Novel Family of Electrophilic Fluorinating Agents

Members of a new series of solid, easily handled, storable, transportable, commercially viable, site-selective electrophilic fluorinating agents of the +N-F class (tradenamed Selectfluor reagents) have been synthesized via direct fluorination of monoquaternary salts of 1,4-diazabicyclooctane.