2628-88-8

Basic information

• Product Name: 2-phenyl-1,6-hexanedioic acid
• Synonyms: 2-phenyl-1,6-hexanedioic acid
• CAS NO: 2628-88-8
• Molecular Weight: 222.241
• Mol File: 2628-88-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1,6-hexanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1,6-hexanedioic acid(2628-88-8)
• EPA Substance Registry System: 2-phenyl-1,6-hexanedioic acid(2628-88-8)

Safety Data

• Hazardous Substances Data: 2628-88-8(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 52755-38-1 1-phenyl-2-buten-1-ol 
• 98-88-4 benzoyl chloride 
• 4553-07-5 ethyl phenylcyanoacetate 
• 140-29-4 phenylacetonitrile 
• 15232-96-9 3-phenyl-1-cyclohexene 
• 14274-12-5 2-Phenyl-adipinsaeure-1-anilid 
• 97024-67-4 5-Formyl-5-phenyl-valeriansaeure-methylester 
• 1444-65-1 (RS)-2-phenylcyclohexanone 
• 109-94-4 formic acid ethyl ester 
• 83-13-6 diethyl 2-phenylmalonate 
• 5332-06-9 4-bromobutanenitrile 
• 628-20-6 4-Chlorobutyronitrile 
• 223690-15-1 methyl 5-bromo-2-phenylpentanoate 

Downstream Products

• 312312-85-9 7-phenyl-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4-(3H,5H)-dione 
• 312312-81-5 2-Amino-7-phenyl-6,7-dihydrocyclopenta[e][1,3]oxazin-4(5H)-one 
• 61604-86-2 (R)-2-phenyl-adipic acid 
• 17540-20-4 (S)-2-phenyl-adipic acid 
• 1924-30-7 diethyl 2-phenylhexanedioate 

Relevant articles and documents

Direct and Selective Synthesis of Adipic and Other Dicarboxylic Acids by Palladium-Catalyzed Carbonylation of Allylic Alcohols

A general and direct synthesis of dicarboxylic acids including industrially important adipic acid by palladium-catalyzed dicarbonylation of allylic alcohol is reported. Specifically, the combination of PdCl2 and a bisphosphine ligand (HeMaRaphos) promotes two different carbonylation reactions with high activity and excellent selectivity.

Synthesis of annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) using 1,3-oxazine-2,4(3H)-diones as key intermediates

Condensation of ethyl 3-phenyl-2-oxocyclopentanecarboxylate 5 with 2-(S-methylthio)isourea followed by hydrolysis with HC1 gave 6,7-dihydro-7-phenylcyclopenta[e][1,3]oxazine-2,4(3H,5H)-dione (10a). 7,8-Dihydro-8-phenyl-6H-cyclohexa[e][1,3]oxazine-2,4(3H,5H)-dione (10b) was synthesised by reacting 2-phenylcyclohexanone (9b) with N-(chlorocarbonyl) isocyanate. The oxazines 10a,b were reacted with ammonia to obtain the corresponding uracil derivatives 12a,b which after silylation were alkylated with diethoxymethane using trimethylsilyl triflate (TMS-triflate) as the catalyst or alkylated with chloromethyl ethyl ether to give annelated MKC-442 analogues 2,3 which are locked in a conformation close to the one of MKC-442. In spite of this, only moderate activities were found against HIV-1 for the annelated analogues of MKC-442. The Royal Society of Chemistry 2000.