26308-28-1

Basic information

• Product Name: Ripazepam
• Synonyms: Ripazepam;1-Ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo[4,3-e][1,4]diazepin-5(1H)-one;Cl-683
• CAS NO: 26308-28-1
• Molecular Formula: C₁₅H₁₆N₄O
• Molecular Weight: 268.318
• Mol File: 26308-28-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 214°C
• Boiling Point: 411.48°C (rough estimate)
• Flash Point: 236°C
• Appearance: /
• Density: 1.1065 (rough estimate)
• Vapor Pressure: 6.97E-09mmHg at 25°C
• Refractive Index: 1.6500 (estimate)
• PKA: 12.96±0.40(Predicted)
• CAS DataBase Reference: Ripazepam(CAS DataBase Reference)
• NIST Chemistry Reference: Ripazepam(26308-28-1)
• EPA Substance Registry System: Ripazepam(26308-28-1)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 26308-28-1(Hazardous Substances Data)

Usage

Uses

Tranquilizer (minor).

InChI:InChI=1/C15H16N4O/c1-3-19-15-13(10(2)18-19)17-12(20)9-16-14(15)11-7-5-4-6-8-11/h4-8H,3,9H2,1-2H3,(H,17,20)

Downstream Products

• 104472-96-0 1-Ethyl-3-methyl-8-phenyl-4,6-dihydro-1H-pyrazolo[4,3-e][1,4]diazepine-5-thione 

Relevant articles and documents

Pyrazolodiazepines. 1,3 (and 2,3) dialkyl 4,6 dihydro 8 arylpyrazolo[4,3 e][1,4] diazepin 5 ones as antianxiety agents

A series of 1, 3 (and 2, 3) dialkyl 4, 6 dihydro 8 arylpyrazolo [4, 3 e][1, 4] diazepin 5 ones was synthesized and evaluated for psychotropic activity. Intermediates are new dialkylnitropyrazolyl aryl ketones prepared from dialkylnitropyrazolecarboxylic acids. Many of these pyrazolodiazepines exhibit high CNS activity in animals. One compound, 1 ethyl 4, 6 dihydro 3 methyl 8 phenylpyrazolo [4, 3 e] [1, 4] diazepin 5 (1H) one is about as potent as diazepam as an antianxiety agent with less sedative properties and is being studied in the clinic.