263349-22-0

Basic information

• Product Name: 3-(PYRIMIDIN-2-YL)BENZALDEHYDE
• Synonyms: 3-(PYRIMIDIN-2-YL)BENZALDEHYDE;AKOS BAR-2386;3-(primidin-2-yl)benzaldehyde;Benzaldehyde, 3-(2-pyrimidinyl)- (9CI);3-(4-(Trifluoromethyl)pyrimidin-2-yl)benzaldehyde;3-(4,6-Dimethoxypyrimidin-2-yl)benzaldehyde;3-(4,6-Dimethylpyrimidin-2-yl)benzaldehyde;3-(4-Methoxypyrimidin-2-yl)benzaldehyde
• CAS NO: 263349-22-0
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• Product Categories: QUINAZOLINE;Phenyls & Phenyl-Het;Aldehydes;Phenyls & Phenyl-Het
• Mol File: 263349-22-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 261.5°Cat760mmHg
• Flash Point: 115.8°C
• Appearance: /
• Density: 1.205g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(PYRIMIDIN-2-YL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(PYRIMIDIN-2-YL)BENZALDEHYDE(263349-22-0)
• EPA Substance Registry System: 3-(PYRIMIDIN-2-YL)BENZALDEHYDE(263349-22-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 263349-22-0(Hazardous Substances Data)

Usage

General Description

3-(pyrimidin-2-yl)benzaldehyde is a chemical compound with a molecular formula C11H8N2O. It is a benzaldehyde derivative, with a pyrimidine ring attached to the benzene ring. 3-(PYRIMIDIN-2-YL)BENZALDEHYDE is used in organic synthesis and pharmaceutical research as a building block for more complex molecules. It has potential applications in the development of new drugs, as well as in the production of dyes and other organic compounds. The presence of both a benzene ring and a pyrimidine ring in its structure makes 3-(pyrimidin-2-yl)benzaldehyde a versatile and valuable intermediate in chemical synthesis.

InChI:InChI=1/C11H8N2O/c14-8-9-3-1-4-10(7-9)11-12-5-2-6-13-11/h1-8H

Upstream product

• 7431-45-0 2-phenylpyrimidine 
• 75-25-2 Bromoform 
• 87199-16-4 3-Formylphenylboronic acid 
• 4595-60-2 2-bromopyrimidine 
• 1722-12-9 2-chloropyrimidine 

Downstream Products

• 1224437-61-9 4-chloro-3-(pyrimidin-2-yl)benzaldehyde 
• 1224437-62-0 2,4-dichloro-3-(pyrimidin-2-yl)benzaldehyde 
• 1396789-56-2 C₂₉H₃₁ClN₄OS 
• 1246561-74-9 (3-(pyrimidin-2-yl)phenyl)methylene diacetate 
• 263349-23-1 (3-phenoxy-phenyl)-(3-pyrimidin-2-yl-benzyl)-amine 
• 898289-50-4 3-(pyrimidin-2-yl)benzonitrile 
• 898289-51-5 2-(3-(chloromethyl)phenyl)pyrimidine 
• 892502-12-4 (3-(pyrimidin-2-yl)phenyl)methanol 
• 579476-25-8 3-pyrimidin-2-yl benzoic acid methyl ester 

Relevant articles and documents

Preparation method of meta-aromatic aldehyde (by machine translation)

The method, uses an aromatic compound as a raw material, to prepare,bromocarbon, ruthenium catalyst, base and a solvent, wherein the solvent is acetonitrile or, dioxane, which is used as an acylating reagent; to obtain m-substituted aromatic aldehyde; by stirring heating temperature to 1,4 - reaction;hour, separation product in the presence of an alkali, additive, solvent, catalyst. 110 - 130 °C, and a solvent is directly added to the reaction device to obtain a meta-substituted aromatic aldehyde. 20 - 25, The method is convenient and low in cost, by using cheap and C - H easily C - H available, carbon tribromide as an acylating agent under. the ruthenium catalysis action. and a solvent. (by machine translation)

Method for preparing meta-position alkenyl aromatic compound

The invention discloses a method for preparing a meta-position alkenyl aromatic compound. The meta-position alkenyl aromatic compound is prepared from a meta-position formyl aromatic compound and diethyl benzylphosphonate through a reaction, and the reaction comprises steps of directly adding the meta-position formyl aromatic compound, the diethyl benzylphosphonate, ammonium acetate, iodine, peroxytert-butanol, sodium carbonate and ethanol into a reaction device, performing stirring and heating to a temperature of 45-55 DEG C, performing the reaction for 7-9 hours, and separating products, soas to obtain the meta-position alkenyl aromatic compound. By adopting the method, the meta-position alkenyl aromatic compound can be conveniently and rapidly synthesized.

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.