263349-73-1

Basic information

• Product Name: 4-Bromo-3-fluorobenzenesulfonamide
• Synonyms: 4-BROMO-3-FLUOROBENZENESULFONAMIDE;4-BROMO-3-FLUOROBENZENESULPHONAMIDE;BUTTPARK 80\03-34;4-Bromo-3-fluorobenzenesulphonamide 98%;4-Bromo-3-fluorobenzenesulphonamide98%;4-Bromo-3-fluorobenz;4-broMo-3-fluorobenzene-1-sulfonaMide;Benzenesulfonamide, 4-bromo-3-fluoro-
• CAS NO: 263349-73-1
• Molecular Formula: C₆H₅BrFNO₂S
• Molecular Weight: 254.08
• EINECS: -0
• Product Categories: Fluorobenzene;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Sulfur Compounds
• Mol File: 263349-73-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 137-141 °C(lit.)
• Boiling Point: 360.1 °C at 760mmHg
• Flash Point: 171.6 °C
• Appearance: /
• Density: 1.83 g/cm³
• Vapor Pressure: 0.0762mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.68±0.60(Predicted)
• CAS DataBase Reference: 4-Bromo-3-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-fluorobenzenesulfonamide(263349-73-1)
• EPA Substance Registry System: 4-Bromo-3-fluorobenzenesulfonamide(263349-73-1)

Safety Data

• Hazard Codes: Xi
• Statements: 22-36/37/38
• Safety Statements: 22-36/37-37-26
• WGK Germany: 3
• PackingGroup: I
• Hazardous Substances Data: 263349-73-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-fluorobenzenesulfonamide is a chemical compound with the formula C6H5BrFNO2S. It is a sulfonamide compound containing both bromine and fluorine atoms attached to a benzene ring. 4-Bromo-3-fluorobenzenesulfonamide may be used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has potential applications in medicinal chemistry and drug development due to its ability to interact with biomolecules and enzymes. The presence of both bromine and fluorine atoms in its structure can also potentially affect its biological activity and pharmacokinetic properties. Additionally, this compound may have other industrial uses such as in the production of dyes or organic synthesis processes.

InChI:InChI=1/C10H11FO/c1-7(2)10(12)8-3-5-9(11)6-4-8/h3-7H,1-2H3

Upstream product

• 351003-51-5 4-bromo-3-fluorobenzene-1-sulfonyl chloride 

Downstream Products

• 896718-71-1 4-ethynyl-3-fluorobenzenesulfonamide 
• 1454649-62-7 4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide 

Relevant articles and documents

Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration

Currently, the therapeutic options for treatment of liver failure are very limited. As mitogen-activated protein kinase kinase 4 (MKK4) has recently been identified by in vivo RNAi experiments to be a major regulator in hepatocyte regeneration, we pursued the development of a small molecule targeting this protein kinase. Starting from the approved BRAFV600E inhibitor vemurafenib (8), that showed a high off-target affinity to MKK4 in an initial screening, we followed a scaffold-hopping approach, changing the core heterocycle from 1H-pyrrolo[2,3-b]pyridine to 1H-pyrazolo[2,3-b]pyridine (10). Affinity to MKK4 could be conserved while the selectivity against off-target protein kinases was slightly improved. Further modifications led to 58 and 59 showing high affinity to MKK4 in the low nanomolar range and excellent selectivity profile from mandatory multiparameter-optimization for the essential anti-targets (MKK7, JNK1) and off-targets (BRAF, MAP4K5, ZAK) in the MKK4 pathway. Herein we report the first selective MKK4 inhibitors in this class.

ARYL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR

In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; trea