263395-57-9

Basic information

• Product Name: 4'-hydroxy-3-(trimethylacetoxy)benzophenone
• Synonyms: 4'-hydroxy-3-(trimethylacetoxy)benzophenone
• CAS NO: 263395-57-9
• Molecular Weight: 298.339
• Mol File: 263395-57-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-hydroxy-3-(trimethylacetoxy)benzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-hydroxy-3-(trimethylacetoxy)benzophenone(263395-57-9)
• EPA Substance Registry System: 4'-hydroxy-3-(trimethylacetoxy)benzophenone(263395-57-9)

Safety Data

• Hazardous Substances Data: 263395-57-9(Hazardous Substances Data)

Upstream product

• 263395-55-7 3-hydroxy-4'-(methoxymethoxy)benzophenone 
• 611-81-4 (3-hydroxyphenyl)(4-hydroxyphenyl)methanone 
• 75731-44-1 4,3'-dimethoxybenzophenone 
• 3282-30-2 pivaloyl chloride 
• 263395-56-8 4'-methoxymethoxy-3-(trimethylacetoxy)benzophenone 

Downstream Products

• 263395-59-1 (E)-1-{4'-[2-(N,N-dimethylamino)ethoxy]phenyl}-1-[3-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene 
• 263395-65-9 4'-[2-(N,N-dimethylamino)ethoxy]-3-hydroxybenzophenone 
• 83647-29-4 1-(4-[2-dimethylaminoethoxy]phenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1-ene 
• 82413-20-5 Droloxifene 
• 263395-58-0 (E)-1-(4'-hydroxyphenyl)-1-[3-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene 

Relevant articles and documents

New highly stereoselective synthesis of (E)-droloxifene via selective protection of 3,4'-dihydroxybenzophenone and McMurry reaction

A new, highly stereoselective synthesis of (E)-droloxifene is reported. Deprotection of 3,4'-dimethoxybenzophenone and selective pivaloylation of the 3'-phenolic position gave 4-hydroxy-3'-(trimethylacetoxy)benzophenone. A McMurry reaction between the preceding benzophenone and propiophenone gave the (E)-olefin as a major product (14:1 E/Z ratio in crude reaction), which was then alkylated with 2-dimethylaminoethyl chloride and deprotected to yield (E)-droloxifene with a > 100:1 E/Z ratio (5 steps, 13%). Attempts to use this strategy as a suitable stereoselective method to obtain (Z)- droloxifene were not successful. (C) 2000 Elsevier Science Ltd.