26346-75-8

Basic information

• Product Name: 2,5-diphenyl-isoxazol-3-one
• Synonyms: 2,5-diphenyl-isoxazol-3-one
• CAS NO: 26346-75-8
• Molecular Weight: 237.258
• Mol File: 26346-75-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-diphenyl-isoxazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-diphenyl-isoxazol-3-one(26346-75-8)
• EPA Substance Registry System: 2,5-diphenyl-isoxazol-3-one(26346-75-8)

Safety Data

• Hazardous Substances Data: 26346-75-8(Hazardous Substances Data)

Upstream product

• 81784-68-1 N-Hydroxy-3-oxo-3,N-diphenyl-propionamide 
• 2579-22-8 Phenylpropargyl aldehyde 
• 586-96-9 Nitrosobenzene 
• 100-65-2 N-Phenylhydroxylamine 
• 7299-58-3 phenylpropiolyl chloride 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 34620-51-4 phenylpropynoic acid N-hydroxy-anilide 

Relevant articles and documents

N-heterocyclic carbene-catalyzed formal [3+2] annulation of alkynyl aldehydes with nitrosobenzenes: A highly regioselective umpolung strategy

N-Heterocyclic carbene-catalyzed formal [3+2] annulation of alkynyl aldehydes and nitrosobenzenes has been reported. This transformation provided the novel C-X bond formation under mild conditions in moderate to satisfactory yields. The catalytic protocol allows for a rapid construction of 2,5-disubstituted isoxazol-3(2H)-ones and 2,3-disubstituted isoxazol-5(2H)-ones from the same materials via a highly regioselectively umpolung stratgy.