2637-37-8 Usage
Description
2-Quinolinethiol is an organic compound with the chemical formula C9H7NS. It is a derivative of quinoline, which is a tricyclic aromatic compound. 2-Quinolinethiol has a thiol (-SH) functional group attached to the second carbon of the quinoline ring, giving it unique chemical and electrochemical properties. It has been studied for its electrochemical behavior using a hanging mercury drop electrode.
Uses
Used in Electrochemical Research:
2-Quinolinethiol is used as a subject of study in electrochemical research for understanding its behavior and potential applications in various fields. The research focuses on its interaction with a hanging mercury drop electrode, which can provide insights into its electrochemical properties and possible uses in sensing, energy storage, or other electrochemical processes.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 2-Quinolinethiol and its derivatives are known to have potential applications in the pharmaceutical industry. They can be used as building blocks for the synthesis of various drugs, particularly those with antimicrobial, antifungal, and anticancer properties. The unique structure of 2-Quinolinethiol allows for the development of new therapeutic agents with improved efficacy and selectivity.
Used in Chemical Synthesis:
2-Quinolinethiol can be used as a starting material or intermediate in the synthesis of various organic compounds. Its thiol functional group can participate in a range of chemical reactions, such as oxidation, substitution, and condensation, making it a versatile building block for the creation of complex molecules with diverse applications in different industries.
Used in Analytical Chemistry:
The electrochemical behavior of 2-Quinolinethiol can be exploited in the development of sensors and analytical methods for the detection and quantification of various analytes. Its interaction with a hanging mercury drop electrode can be utilized to design electrochemical sensors with high sensitivity and selectivity for specific target molecules, which can be applied in environmental monitoring, food safety, and medical diagnostics.
Check Digit Verification of cas no
The CAS Registry Mumber 2637-37-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,3 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2637-37:
(6*2)+(5*6)+(4*3)+(3*7)+(2*3)+(1*7)=88
88 % 10 = 8
So 2637-37-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7NS/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
2637-37-8Relevant articles and documents
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Nakanishi,A.,Oae,S.
, p. 2023 - 2025 (1973)
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Grignard-Reagent-Promoted Desulfonylation/Intramolecular Coupling for the Synthesis of 2-(1-Fluorovinyl)pyridines
Jiang, Gaoxi,Kang, Lei,Qian, Jinlong,Yang, Huameng,Zhang, Jinlong
supporting information, p. 9118 - 9122 (2020/12/02)
A novel process involving Grignard-reagent-promoted desulfonylation/intramolecular coupling of readily available α-fluoro-α,β-unsaturated-(2-pyridyl)sulfones was realized that provided a series of polysubstituted 2-(1-fluorovinyl)pyridines in good yields. The intrinsic coordination between pyridine and Mg(II) along with the "negative fluorine effect"of the substrates should play the key role for the smooth transformation in the absence of transition-metal catalysts.
Chalcogen containing heterocyclic scaffolds: New hybrids with antitumoral activity
Alcolea, Verónica,Plano, Daniel,Encío, Ignacio,Palop, Juan Antonio,Sharma, Arun K.,Sanmartín, Carmen
, p. 407 - 418 (2016/08/04)
In this work, 27 novel hybrid derivatives containing diverse substituents with chalcogen atoms (selenium or sulfur) and several active heterocyclic scaffolds have been synthesized. Compounds were tested against two human cancer cells lines (MCF7 and PC-3) and a normal human mammary epithelial cell line (184B5) in order to determine their activity and selectivity against malignant cells. Ten compounds showed GI50values below 10?μM in at least one of the cancer cell lines and six of them exhibited a selectivity index higher than 9. In general, selenium-containing compounds were more active than their corresponding sulfur analogs but we found some thiocyanate derivatives with comparable or higher activity and selectivity. Among the different substituents, the seleno- and thio-cyanate groups showed the most promising results. On the basis of their potent activity and high selectivity index, compounds 7e and 8f (containing a thiocyanate and a selenocyanate group, respectively) were selected for further biological evaluation. Both the compounds induced caspase-dependent cell death and cell cycle arrest in G2/M phase. In addition, these compounds do not violate any of the Lipinski's Rule of Five and thus possess good potential to become drugs, compound 7e being particularly promising.
