263719-80-8

Basic information

• Product Name: N²-BOC-4-methyl-N⁵-benzyl-1,2,5-thiadiazolidine 1,1-dioxide
• Synonyms: N²-BOC-4-methyl-N⁵-benzyl-1,2,5-thiadiazolidine 1,1-dioxide
• CAS NO: 263719-80-8
• Molecular Weight: 326.417
• Mol File: 263719-80-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N²-BOC-4-methyl-N⁵-benzyl-1,2,5-thiadiazolidine 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: N²-BOC-4-methyl-N⁵-benzyl-1,2,5-thiadiazolidine 1,1-dioxide(263719-80-8)
• EPA Substance Registry System: N²-BOC-4-methyl-N⁵-benzyl-1,2,5-thiadiazolidine 1,1-dioxide(263719-80-8)

Safety Data

• Hazardous Substances Data: 263719-80-8(Hazardous Substances Data)

Upstream product

• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 

Relevant articles and documents

New pseudonucleosides containing chiral oxazolidin-2-ones and Cyclosulfamides as aglycones: Synthesis and antiviral evaluation

A series of chiral cyclosulfamides and oxazolidinon-2-ones have been synthesized starting from aminoacids. Regioselective substitution of these pseudopyrimidic heterocyles was carried out under Mitsunobu conditions. Best substitution results were obtained by preliminary deprotection of cyclosulfamides and their condensation with β -D-ribofuranose. Chiral oxazolidin-2-ones were coupled directly with D-ribofuranose. All compounds were tested against HSV-2, VV and SV viruses. Two compounds 6b and 6e showed significant activities against HSV-type 1. Copyright Taylor & Francis Group, LLC.

Synthesis of 1,2,5-thiadiazolidines 1,1-dioxides (Cyclosulfamides) starting from amino acids and chlorosulfonyl isocyanate

We report here a practical access to a series of five-membered cyclosulfamides (1,2,5-thiadiazolidines 1,1-dioxides) N2 substituted by the BOC group. These compounds are synthesized starting from chlorosulfonyl isocyanate and nitrogen mustards or amino acids. The derivatization of amino acids can lead to an alkyl group on C-4 with a well-defined configuration; in this case the N5 position was protected by a benzyl group. These compounds are valuable tools for asymmetric synthesis. (C) 2000 Elsevier Science Ltd.