26389-59-3

Basic information

• Product Name: N-PROPYLCYCLOPROPANECARBOXAMIDE
• Synonyms: cyclopropanecarboxamide, N-propyl-; N-PROPYLCYCLOPROPANECARBOXAMIDE
• CAS NO: 26389-59-3
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Product Categories: Cycloalkanes
• Mol File: 26389-59-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 269.3 °C at 760 mmHg
• Flash Point: 150.7 °C
• Appearance: /
• Density: 1.006 g/cm³
• Vapor Pressure: 0.00729mmHg at 25°C
• Refractive Index: 1.48
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-PROPYLCYCLOPROPANECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PROPYLCYCLOPROPANECARBOXAMIDE(26389-59-3)
• EPA Substance Registry System: N-PROPYLCYCLOPROPANECARBOXAMIDE(26389-59-3)

Safety Data

• Hazardous Substances Data: 26389-59-3(Hazardous Substances Data)

Usage

General Description

N-PROPYLCYCLOPROPANECARBOXAMIDE is a chemical compound with the formula C8H15NO and molecular weight 141.21 g/mol. It is an amide derivative of cyclopropanecarboxylic acid, with a propyl group attached to the nitrogen atom. This chemical is used primarily as an intermediate in the synthesis of other organic compounds. It may also be used as a building block in the pharmaceutical and agrochemical industries. N-PROPYLCYCLOPROPANECARBOXAMIDE is a white solid that is sparingly soluble in water, but soluble in organic solvents. It is important to handle this compound with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C7H13NO/c1-2-5-8-7(9)6-3-4-6/h6H,2-5H2,1H3,(H,8,9)

Upstream product

• 107-10-8 propylamine 
• 4023-34-1 cyclopropanecarboxylic acid chloride 

Downstream Products

• 26389-60-6 N-(n-propyl)-N-(cyclopropanemethyl)amine 
• 38185-08-9 4-(cyclopropylmethyl-propyl-amino)-3,5-dinitro-benzenesulfonyl chloride 

Relevant articles and documents

Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides

N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (1) and N1-phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites but display poor in vivo activity. Seventeen new dinitroaniline sulfonamide and eleven new benzamide analogs of these leads are reported here. Nine of the sulfonamides display in vitro IC50 values under 500 nM against African trypanosomes, and the most active antikinetoplastid compounds also inhibit the in vitro assembly of purified leishmanial tubulin with potencies similar to that of 2. While several of the potent compounds are rapidly degraded by rat liver S9 fractions in vitro, N1-(3-hydroxy)phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (21) displays an IC50 value of 260 nM against African trypanosomes in vitro and is more stable than 2 in the in vitro metabolism assay.