26395-99-3 Usage
Description
7-Aminodesacetoxycephalosporanic acid, also known as Cefadroxil EP Impurity B, is a metabolite derived from Cephalexin (C256800). It is a key component in the synthesis of various cephalosporin antibiotics, which are widely used for their antimicrobial properties.
Uses
Used in Pharmaceutical Industry:
7-Aminodesacetoxycephalosporanic acid is used as an intermediate in the production of cephalosporin antibiotics for its role in the synthesis process. These antibiotics are essential in treating a range of bacterial infections due to their effectiveness in disrupting bacterial cell wall synthesis, leading to the death of the bacteria.
Additionally, as a metabolite of Cephalexin, 7-Aminodesacetoxycephalosporanic acid may also be relevant in the study of drug metabolism and pharmacokinetics, potentially aiding in the development of more effective and safer antibiotic therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 26395-99-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,3,9 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 26395-99:
(7*2)+(6*6)+(5*3)+(4*9)+(3*5)+(2*9)+(1*9)=143
143 % 10 = 3
So 26395-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O3S/c1-3-2-14-7-4(9)6(11)10(7)5(3)8(12)13/h4,7H,2,9H2,1H3,(H,12,13)/t4-,7-/m0/s1
26395-99-3Relevant articles and documents
PROCESS FOR THE PRODUCTION OF CEPHALOSPORINS
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Page/Page column 10-11, (2012/03/27)
The present invention relates to a composition comprising ≥85 wt% of an N-deacylated cephalosporin, a process for making the same and the use of said N-deacylated cephalosporin in the preparation of highly pure semi synthetic cephalosporins.
The multilayer polymer film
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, (2007/10/09)
The use of multilayer film structure comprising at least two unfilled layers of polymeric material substantially devoid of opacifying agent and at least two filled layers of polymeric material wherein said filled layers comprise at least 5% by weight of o
Glutaryl Acylases: One-Reaction Enzymes or Versatile Enantioselective Biocatalysts?
Raimondi, Stefano,Monti, Daniela,Pagnoni, Ugo Maria,Riva, Sergio
, p. 783 - 789 (2007/10/03)
A significant broad substrate specificity, that crosses over the usual β-lactam derivatives, has been observed with an industrial glutaryl-7-aminocephalosporanic acid acylase (GA). This enzyme possesses significant enantioselective amidase and even esterase activity, with a stereopreference for the S-enantiomer. The easy separation of products from unreacted reagents, possessing different physical-chemical properties, is achieved by solvent extraction, avoiding chromatography or distillation during reaction work-up.