26423-00-7

Basic information

• Product Name: 4-(Butylamino)-6-chloropyrimidine
• Synonyms: 4-(Butylamino)-6-chloropyrimidine;N-Butyl-6-chloropyrimidin-4-amine;4-(Butylamino)-6-chloropyrimidine 98%;4-chloro-6-butylaminopyrimidine;6-Butylamino-4-chloropyrimidine;4-(Butylamino)-6-chloropyrimidine98%
• CAS NO: 26423-00-7
• Molecular Formula: C8H12ClN3
• Molecular Weight: 185.65398
• Product Categories: blocks
• Mol File: 26423-00-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 314.5 °C at 760 mmHg
• Flash Point: 144 °C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0.000464mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 4-(Butylamino)-6-chloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Butylamino)-6-chloropyrimidine(26423-00-7)
• EPA Substance Registry System: 4-(Butylamino)-6-chloropyrimidine(26423-00-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 26423-00-7(Hazardous Substances Data)

Usage

General Description

4-(Butylamino)-6-chloropyrimidine, also known as BAC-6, is a chemical compound with the molecular formula C9H14ClN3. It is a pyrimidine derivative that contains a butylamino group and a chlorine atom. BAC-6 is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also known for its ability to inhibit the growth of certain cancer cells by targeting specific enzymes in the body. Additionally, it has potential applications in the field of organic chemistry and chemical research due to its unique structure and reactive properties. Overall, 4-(Butylamino)-6-chloropyrimidine is a versatile chemical compound with a range of potential uses in various industries.

InChI:InChI=1/C8H12ClN3/c1-2-3-4-10-8-5-7(9)11-6-12-8/h5-6H,2-4H2,1H3,(H,10,11,12)

Upstream product

• 4765-77-9 6-Chloro-3,4-dihydro-4-oxopyrimidine 
• 109-73-9 N-butylamine 
• 1193-21-1 4,6-dichloropyrimidine 

Relevant articles and documents

The first example of the Fischer-Hepp type rearrangement in pyrimidines

A N-nitroso moiety can be used for the activation of chloropyrimidines toward a nucleophilic substitution reaction with amines. The subsequent treatment of the obtained products with aq H2SO4 can lead to either N-denitrosation to obtain 4,6-pyrimidinediamines or to a Fischer-Hepp type rearrangement to obtain 5-nitroso-4,6-pyrimidinediamines. It was found that the outcome of the reaction strongly depends on the structure of the pyrimidines. Activation of the pyrimidine ring by three groups with a positive mesomeric effect is crucial for the intramolecular nitroso group migration.

An efficient direct amination of cyclic amides and cyclic ureas

An efficient one-step amination of cyclic amides and ureas has been developed. Treatment of cyclic amides and cyclic ureas with BOP in the presence of DBU in various solvents led to the formation of cyclic amidines and cyclic guanidines in good to excellent yields. Concise syntheses of biologically intriguing kinetin and potent kinase inhibitor olomoucin were thus achieved in just one and two steps, respectively.